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Biological Activity for NPEC-caged-D-AP5
NPEC-caged-D-AP5 is a D-AP5 (Cat.No. 0106) caged with the photosensitive 1-(2-nitrophenyl)ethoxycarbonyl (NPEC) group. NMDA receptor antagonist.
Technical Data for NPEC-caged-D-AP5
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NPEC-caged-D-AP5
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NPEC-caged-D-AP5
The following data is based on the product molecular weight 390.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.56 mL||12.81 mL||25.62 mL|
|5 mM||0.51 mL||2.56 mL||5.12 mL|
|10 mM||0.26 mL||1.28 mL||2.56 mL|
|50 mM||0.05 mL||0.26 mL||0.51 mL|
Product Datasheets for NPEC-caged-D-AP5
References for NPEC-caged-D-AP5
References are publications that support the biological activity of the product.
Murphy et al (1997) Activation of NMDA receptors is necessary for the induction of associative long-term potentiation in area CA1 of the rat hippocampal slice. J.Physiol. 504 379 PMID: 9365912
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Citations for NPEC-caged-D-AP5
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.