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NPC 15437 dihydrochloride
Discontinued ProductNPC 15437 dihydrochloride (Cat. No. 1628) has been withdrawn from sale for commercial reasons.
Highly selective, competitive and reversible inhibitor of protein kinase C (IC50 = 19 mM); interacts at the regulatory domain of the enzyme. May modulate P-glycoprotein in tumor cells in vitro via inhibiton of PKC. Centrally active following systemic administration in vivo.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Mathis et al (1992) The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur.J.Pharmacol. 220 107 PMID: 1425976
Sha et al (1996) Evaluation of 2,6-diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437), a protein kinase C inhibitor, as a modulator of P-glycoprotein-mediated resistance in vitro. Invest.New Drugs 13 285 PMID: 8824346
Sullivan et al (1992) 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain. Mol.Pharmacol. 41 38 PMID: 1732721
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