NPC 15437 dihydrochloride

Discontinued Product

Unfortunately NPC 15437 dihydrochloride (Cat. No. 1628) has been withdrawn from sale for commercial reasons.
Cat.No. 1628 - NPC 15437 dihydrochloride | C25H50N4O2.2HCl | CAS No. 136449-85-9
Description: Selective protein kinase C inhibitor
Chemical Name: (2S)-2,6-Diamino-N-[[1-(1-oxotridecyl)-2-piperidinyl]methyl]hexanamide dihydrochloride

Biological Activity

Highly selective, competitive and reversible inhibitor of protein kinase C (IC50 = 19 mM); interacts at the regulatory domain of the enzyme. May modulate P-glycoprotein in tumor cells in vitro via inhibiton of PKC. Centrally active following systemic administration in vivo.

Technical Data

M. Wt 511.62
Formula C25H50N4O2.2HCl
Storage Desiccate at +4°C
CAS Number 136449-85-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 511.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.77 mL 19.55 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
10 mM 0.2 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Mathis et al (1992) The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice. Eur.J.Pharmacol. 220 107 PMID: 1425976

Sha et al (1996) Evaluation of 2,6-diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437), a protein kinase C inhibitor, as a modulator of P-glycoprotein-mediated resistance in vitro. Invest.New Drugs 13 285 PMID: 8824346

Sullivan et al (1992) 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain. Mol.Pharmacol. 41 38 PMID: 1732721

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