Norleual

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Cat.No. 5369 - Norleual | Nle-Tyr-Leu-(Ψ(CH2-NH)-His-Pro-Phe | CAS No. 334994-34-2
Description: Highly potent HGF/c-MET inhibitor; also AT4 antagonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Angiotensin IV analog. Highly potent HGF/c-MET inhibitor (IC50 = 3 pM). Inhibits HGF-induced MDCK cell proliferation and invasion in vitro. Also AT4 receptor antagonist; disrupts LTP stabilization. Antiangiogenic.

Technical Data

M. Wt 774.95
Formula C41H58N8O7
Sequence XYLHPF

(Modifications: X = Nle, Leu-3-His-4 peptide bond replaced with CH2NH)

Storage Store at -20°C
CAS Number 334994-34-2
PubChem ID 91691127
InChI Key LOHDEFSMLITXTG-RZAPKHMUSA-N
Smiles [H]N(C(CC1=CC=C(O)C=C1)C(=O)N[C@H](CN[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O)CC(C)C)C(=O)[C@@H](N)CCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in water

References

References are publications that support the biological activity of the product.

Yamamoto et al (2010) The angiotensin IV analog Nle-Tyr-Leu-psi-(CH2-NH2)3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor. J.Pharmacol.Exp.Ther. 333 161 PMID: 20086056


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Keywords: Norleual, Norleual supplier, potent, HGF, c-MET, hepatocyte, growth, factors, HGF/c-MET, inhibits, inhibitors, antiangiogenic, angiogenesis, tyrosine, kinases, angiotensin, IV, analog, receptors, AT4, antagonists, MET, Receptors, 5369, Tocris Bioscience

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