Angiotensin IV analog. Highly potent HGF/c-MET inhibitor (IC50 = 3 pM). Inhibits HGF-induced MDCK cell proliferation and invasion in vitro. Also AT4 receptor antagonist; disrupts LTP stabilization. Antiangiogenic.
(Modifications: X = Nle, Leu-3-His-4 peptide bond replaced with CH2NH)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 774.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.29 mL||6.45 mL||12.9 mL|
|5 mM||0.26 mL||1.29 mL||2.58 mL|
|10 mM||0.13 mL||0.65 mL||1.29 mL|
|50 mM||0.03 mL||0.13 mL||0.26 mL|
References are publications that support the products' biological activity.
Yamamoto et al (2010) The angiotensin IV analog Nle-Tyr-Leu-psi-(CH2-NH2)3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor. J.Pharmacol.Exp.Ther. 333 161 PMID: 20086056
If you know of a relevant reference for Norleual, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Norleual, supplier, potent, HGF, c-MET, hepatocyte, growth, factors, HGF/c-MET, inhibits, inhibitors, antiangiogenic, angiogenesis, tyrosine, kinases, angiotensin, IV, analog, receptors, AT4, antagonists, MET, Receptors, MET, Receptors, Tocris Bioscience
Citations for Norleual
Citations are publications that use Tocris products.
Currently there are no citations for Norleual. Do you know of a great paper that uses Norleual from Tocris? If so please let us know.
Reviews for Norleual
There are currently no reviews for this product. Be the first to review Norleual and earn rewards!
Have you used Norleual?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.