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Cat.No. 5369 - Norleual | Nle-Tyr-Leu-(Ψ(CH2-NH)-His-Pro-Phe | CAS No. 334994-34-2
Description: Highly potent HGF/c-MET inhibitor; also AT4 antagonist

Biological Activity

Angiotensin IV analog. Highly potent HGF/c-MET inhibitor (IC50 = 3 pM). Inhibits HGF-induced MDCK cell proliferation and invasion in vitro. Also AT4 receptor antagonist; disrupts LTP stabilization. Antiangiogenic.

Technical Data

M. Wt 774.95
Formula C41H58N8O7
Sequence XYLHPF

(Modifications: X = Nle, Leu-3-His-4 peptide bond replaced with CH2NH)

Storage Store at -20°C
CAS Number 334994-34-2
PubChem ID 91691127
Smiles [H]N(C(CC1=CC=C(O)C=C1)C(=O)N[C@H](CN[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O)CC(C)C)C(=O)[C@@H](N)CCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 774.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.29 mL 6.45 mL 12.9 mL
5 mM 0.26 mL 1.29 mL 2.58 mL
10 mM 0.13 mL 0.65 mL 1.29 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Yamamoto et al (2010) The angiotensin IV analog Nle-Tyr-Leu-psi-(CH2-NH2)3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor. J.Pharmacol.Exp.Ther. 333 161 PMID: 20086056

If you know of a relevant reference for Norleual, please let us know.

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Keywords: Norleual, supplier, potent, HGF, c-MET, hepatocyte, growth, factors, HGF/c-MET, inhibits, inhibitors, antiangiogenic, angiogenesis, tyrosine, kinases, angiotensin, IV, analog, receptors, AT4, antagonists, MET, Receptors, MET, Receptors, Tocris Bioscience

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