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Nor NOHA monoacetate
Reversible, competitive arginase inhibitor (IC50 = 2 μM). Exhibits 10-fold selectivity for human type II arginase over type I. Enhances the effect of acetylcholine on isolated aortic and mesenteric arterial rings. Inhibits growth of lung carcinoma implants in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 236.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.23 mL||21.17 mL||42.33 mL|
|5 mM||0.85 mL||4.23 mL||8.47 mL|
|10 mM||0.42 mL||2.12 mL||4.23 mL|
|50 mM||0.08 mL||0.42 mL||0.85 mL|
References are publications that support the biological activity of the product.
Custot et al (1997) The new α-amino acid Nω-hydroxy-nor-L-arginine: a high affinity inhibitor of arginase well adapted to bind to its manganese cluster. J.Am.Chem.Soc. 119 4086
Colleluori and Ash et al (2001) Classical and slow-binding inhibitors of human type II arginase. Biochemistry 40 9356 PMID: 11478904
Huynh et al (2009) The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. Br.J.Pharmacol. 156 84 PMID: 19133993
Rodriguez et al (2004) Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res. 64 5839 PMID: 15313928
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Keywords: Nor NOHA monoacetate, Nor NOHA monoacetate supplier, arginase, inhibitors, inhibits, reversible, competitive, 189302-40-7, Other, Hydrolases, Immune, Checkpoints, 6370, Tocris Bioscience
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