Nor NOHA monoacetate

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Cat.No. 6370 - Nor NOHA monoacetate | C5H12N4O3.C2H4O2
Description: Arginase inhibitor
Chemical Name: (2S)-2-Amino-4-[[(hydroxyamino)iminomethyl]amino]butanoic acid monoacetate
Datasheet
Citations
Reviews
Literature

Biological Activity

Reversible, competitive arginase inhibitor (IC50 = 2 μM). Exhibits 10-fold selectivity for human type II arginase over type I. Enhances the effect of acetylcholine on isolated aortic and mesenteric arterial rings. Inhibits growth of lung carcinoma implants in mice.

Technical Data

M. Wt 236.23
Formula C5H12N4O3.C2H4O2
Storage Store at -20°C
Smiles N[C@@H](CCNC(NO)=N)C(O)=O.O=C(O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 236.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.23 mL 21.17 mL 42.33 mL
5 mM 0.85 mL 4.23 mL 8.47 mL
10 mM 0.42 mL 2.12 mL 4.23 mL
50 mM 0.08 mL 0.42 mL 0.85 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Custot et al (1997) The new α-amino acid Nω-hydroxy-nor-L-arginine: a high affinity inhibitor of arginase well adapted to bind to its manganese cluster. J.Am.Chem.Soc. 119 4086

Colleluori and Ash et al (2001) Classical and slow-binding inhibitors of human type II arginase. Biochemistry 40 9356 PMID: 11478904

Huynh et al (2009) The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. Br.J.Pharmacol. 156 84 PMID: 19133993

Rodriguez et al (2004) Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res. 64 5839 PMID: 15313928


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Keywords: Nor NOHA monoacetate, Nor NOHA monoacetate supplier, arginase, inhibitors, inhibits, reversible, competitive, 189302-40-7, Other, Hydrolases, 6370, Tocris Bioscience

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