Nonactin

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Cat.No. 2505 - Nonactin | C40H64O12 | CAS No. 6833-84-7
Description: Monovalent cation ionophore
Alternative Names: Ammonium Ionophore I
Chemical Name: (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-Octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
Purity: ≥93%
Datasheet
Citations
Reviews
Literature

Biological Activity

Monovalent cation ionophore that displays selectivity for K+ and NH4+ (K+ = NH4+ > Na+ > Mg2+ > Li+ >> Ca2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.

Technical Data

M. Wt 736.94
Formula C40H64O12
Storage Desiccate at -20°C
Purity ≥93%
CAS Number 6833-84-7
PubChem ID 72519
InChI Key RMIXHJPMNBXMBU-QIIXEHPYSA-N
Smiles [H][C@]3(CC[C@@](C[C@@H](C)OC([C@H](C)[C@@]4([H])CC[C@](C[C@H](C)OC([C@H]5C)=O)([H])O4)=O)([H])O3)[C@H](C)C(O[C@@H](C)C[C@@]1([H])O[C@]([C@@H](C)C(O[C@H](C)C[C@]2([H])O[C@@]5([H])CC2)=O)([H])CC1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 7.37 10

Preparing Stock Solutions

The following data is based on the product molecular weight 736.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.57 mL 67.85 mL 135.7 mL
0.5 mM 2.71 mL 13.57 mL 27.14 mL
1 mM 1.36 mL 6.78 mL 13.57 mL
5 mM 0.27 mL 1.36 mL 2.71 mL

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References

References are publications that support the biological activity of the product.

Borrel et al (1994) Mobile ionophores are a novel class of P-glycoprotein inhibitors. The effects of ionophores on 4'O-tetrahydropyranyl-adriamycin incorporation in K562 drug-resistant cells. Eur.J.Biochem. 223 125 PMID: 7518390

Woo et al (1999) Nonactin biosynthesis: the product of nonS catalyzes the formation of the furan ring of nonactic acid. Antimicrob.Agents Chemother. 43 1662 PMID: 10390219

Garcia et al (2003) Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane. J.Pharm.Biomed.Anal. 31 11 PMID: 12560044


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Keywords: Nonactin, Nonactin supplier, Monovalent, cation, ionophores, NH4+, K+, Potassium, antibiotics, Ammonium, Ionophore, I, Ionophores, 2505, Tocris Bioscience

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