NITD 008

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Description: Antiflaviviral; active against Zika, Dengue and Hepatitis C viruses
Chemical Name: 7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity: ≥97% (HPLC)

Biological Activity for NITD 008

NITD 008 is a selective flavivirus inhibitor. Adenosine analog. Inhibits dengue virus (EC50 = 0.64 μM), hepatitis C virus and cellular entry of Zika virus. Reduces increases of cytokines and NS1 and prevents death in dengue-infected mice. Active in vivo. Orally bioavailable.

Technical Data for NITD 008

M. Wt 290.27
Formula C13H14N4O4
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1044589-82-3
PubChem ID 44633776
Smiles NC1=C2C=CN(C2=NC=N1)[C@@H]3O[C@@H]([C@H]([C@@]3(C#C)O)O)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NITD 008

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.81 20

Preparing Stock Solutions for NITD 008

The following data is based on the product molecular weight 290.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 17.23 mL 86.13 mL 172.25 mL
1 mM 3.45 mL 17.23 mL 34.45 mL
2 mM 1.72 mL 8.61 mL 17.23 mL
10 mM 0.34 mL 1.72 mL 3.45 mL

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References for NITD 008

References are publications that support the biological activity of the product.

Yin et al (2009) An adenosine nucleoside inhibitor of dengue virus. Proc.Natl.Acad.Sci.USA. 106 20435 PMID: 19918064

Barrows et al (2016) A screen of FDA-approved drugs for inhibitors of Zika virus infection. Cell.Host.Microbe. 20 259 PMID: 27476412

If you know of a relevant reference for NITD 008, please let us know.

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Citations for NITD 008

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