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Selective flavivirus inhibitor. Adenosine analog. Inhibits dengue virus (EC50 = 0.64 μM), hepatitis C virus and cellular entry of Zika virus. Reduces increases of cytokines and NS1 and prevents death in dengue-infected mice. Active in vivo. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 290.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||17.23 mL||86.13 mL||172.25 mL|
|1 mM||3.45 mL||17.23 mL||34.45 mL|
|2 mM||1.72 mL||8.61 mL||17.23 mL|
|10 mM||0.34 mL||1.72 mL||3.45 mL|
References are publications that support the biological activity of the product.
Yin et al (2009) An adenosine nucleoside inhibitor of dengue virus. Proc.Natl.Acad.Sci.USA. 106 20435 PMID: 19918064
Barrows et al (2016) A screen of FDA-approved drugs for inhibitors of Zika virus infection. Cell.Host.Microbe. 20 259 PMID: 27476412
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Keywords: NITD008, NITD008 supplier, NITD008, antiviral, selective, flavivirus, inhibitors, inhibits, dengue, hepatitis, C, Zika, virus, active, in, vivo, orally, bioavailable, Flaviviruses, Hepatitis, Viruses, 6045, Tocris Bioscience
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