Selective flavivirus inhibitor. Adenosine analog. Inhibits dengue virus (EC50 = 0.64 μM), hepatitis C virus and cellular entry of Zika virus. Reduces increases of cytokines and NS1 and prevents death in dengue-infected mice. Active in vivo. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 290.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.45 mL||17.23 mL||34.45 mL|
|5 mM||0.69 mL||3.45 mL||6.89 mL|
|10 mM||0.34 mL||1.72 mL||3.45 mL|
|50 mM||0.07 mL||0.34 mL||0.69 mL|
References are publications that support the biological activity of the product.
Yin et al (2009) An adenosine nucleoside inhibitor of dengue virus. Proc.Natl.Acad.Sci.USA. 106 20435 PMID: 19918064
Barrows et al (2016) A screen of FDA-approved drugs for inhibitors of Zika virus infection. Cell.Host.Microbe. 20 259 PMID: 27476412
If you know of a relevant reference for NITD 008, please let us know.
View Related Products by Target
Keywords: NITD008, NITD008 supplier, NITD008, antiviral, selective, flavivirus, inhibitors, inhibits, dengue, hepatitis, C, Zika, virus, active, in, vivo, orally, bioavailable, Antivirals, 6045, Tocris Bioscience
Citations for NITD 008
Citations are publications that use Tocris products.
Currently there are no citations for NITD 008. Do you know of a great paper that uses NITD 008 from Tocris? Please let us know.
Reviews for NITD 008
There are currently no reviews for this product. Be the first to review NITD 008 and earn rewards!
Have you used NITD 008?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.