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Non-steroidal and silent antiandrogen. Binds to androgen receptors and also inhibits androgen biosynthesis in vitro. In rats in vivo it inhibits androgen-induced prostate weight increase and inhibits negative androgen-dependent gonadotropin feedback leading to an increase in luteinising hormone and testosterone. Orally active.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||7.93||25 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 317.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||12.61 mL||63.05 mL||126.1 mL|
|1.25 mM||2.52 mL||12.61 mL||25.22 mL|
|2.5 mM||1.26 mL||6.3 mL||12.61 mL|
|12.5 mM||0.25 mL||1.26 mL||2.52 mL|
References are publications that support the biological activity of the product.
Ayub and Levell (1987) Inhibition of rat testicular 17-α-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro. J.Steroid Biochem. 28 43 PMID: 2956461
Raynaud et al (1979) Action of a non-steroid anti-androgen, RU 23908, in peripheral and central tissues. J.Steroid Biochem. 11 93 PMID: 385986
Raynaud et al (1984) The pure antiandrogen RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer. The Prostate 5 299 PMID: 6374639
Raynaud et al (1985) Pharmacology and clinical studies with RU 23908 (Anandron). Prog.Clin.Biol.Res. 185A 99 PMID: 4034583
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Keywords: Nilutamide, Nilutamide supplier, Androgen, receptor, antagonists, Orally, active, Dihydrotestosterone, Receptors, RU23908, chemotherapeutics, RU, 23908, Receptor, 1759, Tocris Bioscience
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