Discontinued Product

Nilutamide (Cat. No. 1759) has been withdrawn from sale for commercial reasons.
Description: Androgen receptor antagonist. Orally active
Alternative Names: RU 23908
Chemical Name: 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione
Purity: ≥99% (HPLC)

Biological Activity for Nilutamide

Non-steroidal and silent antiandrogen. Binds to androgen receptors and also inhibits androgen biosynthesis in vitro. In rats in vivo it inhibits androgen-induced prostate weight increase and inhibits negative androgen-dependent gonadotropin feedback leading to an increase in luteinising hormone and testosterone. Orally active.

Technical Data for Nilutamide

M. Wt 317.22
Formula C12H10F3N3O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 63612-50-0
PubChem ID 4493
Smiles CC1(C)NC(=O)N(C1=O)C1=CC=C(C(=C1)C(F)(F)F)N(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Nilutamide

References are publications that support the biological activity of the product.

Ayub and Levell (1987) Inhibition of rat testicular 17-α-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro. J.Steroid Biochem. 28 43 PMID: 2956461

Raynaud et al (1979) Action of a non-steroid anti-androgen, RU 23908, in peripheral and central tissues. J.Steroid Biochem. 11 93 PMID: 385986

Raynaud et al (1984) The pure antiandrogen RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer. The Prostate 5 299 PMID: 6374639

Raynaud et al (1985) Pharmacology and clinical studies with RU 23908 (Anandron). Prog.Clin.Biol.Res. 185A 99 PMID: 4034583

View Related Products by Target

View Related Products by Product Action

View all Androgen Receptor Antagonists

Keywords: Nilutamide, Nilutamide supplier, Androgen, receptor, antagonists, Orally, active, Dihydrotestosterone, Receptors, RU23908, chemotherapeutics, RU, 23908, Receptor, 1759, Tocris Bioscience

Citations for Nilutamide

Citations are publications that use Tocris products.

Currently there are no citations for Nilutamide.

Reviews for Nilutamide

There are currently no reviews for this product. Be the first to review Nilutamide and earn rewards!

Have you used Nilutamide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review