NG 25
Biological Activity
TGF-β-activated kinase (TAK1) inhibitor (IC50 = 149 nM). Also inhibits LYN, MAP4K2 and Abl kinase activity (IC50 values are 12.9, 21.7 and 75.2 nM, respectively). Suppresses CpG A and CpG B-stimulated secretion of IFN-α and TLR7/8 agonist CL097-stimulated secretion of IFN-β in Gen 2.2 leukemia cells in vitro.
Licensing Information
Sold under license from Dana-Farber Cancer Institute.
Technical Data
M. Wt | 537.58 |
Formula | C29H30F3N5O2 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 1315355-93-1 |
PubChem ID | 53340664 |
InChI Key | SMPGEBOIKULBCT-UHFFFAOYSA-N |
Smiles | CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(OC4=CC=NC5=C4C=CN5)=C(C)C=C3)=O)C=C2)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 10.75 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 537.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.86 mL | 9.3 mL | 18.6 mL |
5 mM | 0.37 mL | 1.86 mL | 3.72 mL |
10 mM | 0.19 mL | 0.93 mL | 1.86 mL |
50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Tan et al (2015) Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J.Med.Chem. 58 183 PMID: 25075558
Pauls et al (2012) Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells. J.Biol.Chem. 287 19216 PMID: 22511786
Dzamko et al (2012) The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. PLoS ONE 7 e39132 PMID: 22723946
If you know of a relevant reference for NG 25, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NG 25, supplier, NG25, TAK1, TGFbeta, TGFb, TGFβ, activated, kinases, inhibitors, inhibits, MAP4K2, LYN, Abl, Other, Kinases, Other, Kinases, Tocris Bioscience
Citations for NG 25
Citations are publications that use Tocris products.
Currently there are no citations for NG 25. Do you know of a great paper that uses NG 25 from Tocris? If so please let us know.
Reviews for NG 25
There are currently no reviews for this product. Be the first to review NG 25 and earn rewards!
Have you used NG 25?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and Europe
Submit a Review