Neuropeptide W-23 (human)

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Cat.No. 3009 - Neuropeptide W-23 (human) | Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-Leu-Met-Gly-Leu | CAS No. 383415-79-0
Description: Endogenous NPBW1 and NPBW2 receptor agonist
Alternative Names: NPW-23
Datasheet
Citations
Reviews
Literature

Biological Activity

Endogenous peptide agonist of Neuropeptide B/Neuropeptide W receptors NPBW1 and NPBW2 (previously known as GPR7 and GPR8 respectively). Increases food intake following injection into the paraventricular nucleus.

Technical Data

M. Wt 2584.03
Formula C119H183N35O28S
Sequence WYKHVASPRYHTVGRAAGLLMGL
Storage Desiccate at -20°C
CAS Number 383415-79-0
PubChem ID 16209885
InChI Key AKMMHLDUORFPQZ-BKMDBHAQSA-N
Smiles [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Shimomura et al (2002) Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. J.Biol.Chem. 277 35826 PMID: 12130646

Brezillon et al (2003) Identification of natural ligands for the orphan G prortein-coupled receptors GPR7 and GPR8. J.Biol.Chem. 278 776 PMID: 12401809

Levine et al (2005) Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake. Am.J.Physiol.Regul.Integr.Comp.Physiol. 288 R1727 PMID: 15886360

Hondo et al (2008) The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion. Results Probl.Cell Differ. 46 239 PMID: 18204824


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Keywords: Neuropeptide W-23 (human), Neuropeptide W-23 (human) supplier, Endogenous, NPBW1, NPBW2, agonists, Receptors, Neuropeptides, B, W, NPW23, GPR7, GPR8, NPW-23, Other, Peptide, 3009, Tocris Bioscience

Citations for Neuropeptide W-23 (human)

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Literature in this Area

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