Neuropeptide W-23 (human)
Endogenous peptide agonist of Neuropeptide B/Neuropeptide W receptors NPBW1 and NPBW2 (previously known as GPR7 and GPR8 respectively). Increases food intake following injection into the paraventricular nucleus.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 2584.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.39 mL||1.93 mL||3.87 mL|
|5 mM||0.08 mL||0.39 mL||0.77 mL|
|10 mM||0.04 mL||0.19 mL||0.39 mL|
|50 mM||0.01 mL||0.04 mL||0.08 mL|
References are publications that support the biological activity of the product.
Shimomura et al (2002) Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. J.Biol.Chem. 277 35826 PMID: 12130646
Brezillon et al (2003) Identification of natural ligands for the orphan G prortein-coupled receptors GPR7 and GPR8. J.Biol.Chem. 278 776 PMID: 12401809
Levine et al (2005) Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake. Am.J.Physiol.Regul.Integr.Comp.Physiol. 288 R1727 PMID: 15886360
Hondo et al (2008) The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion. Results Probl.Cell Differ. 46 239 PMID: 18204824
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Keywords: Neuropeptide W-23 (human), Neuropeptide W-23 (human) supplier, Endogenous, NPBW1, NPBW2, agonists, Receptors, Neuropeptides, B, W, NPW23, GPR7, GPR8, NPW-23, Other, Peptide, 3009, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.