Neuropeptide SF (mouse, rat)

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Cat.No. 3647 - Neuropeptide SF (mouse, rat) | Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe-NH2 | CAS No. 230960-31-3
Description: NPFF1 and NPFF2 agonist
Literature (2)

Biological Activity

Neuropeptide FF receptor agonist (Ki values are 48.4 and 12.1 nM for NPFF1 and NPFF2, respectively). Potentiates the antinociceptive action of morphine in vivo and reverses the loss of morphine potency in tolerant animals. Also increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) (EC50 ~ 50 μM).

Technical Data

M. Wt 888.03
Formula C40H65N13O10

(Modifications: Phe-8 = C-terminal amide)

Storage Store at -20°C
CAS Number 230960-31-3
PubChem ID 90488868
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in 20% acetonitrile / water


References are publications that support the biological activity of the product.

Deval et al (2003) Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability. Neuropharmacology 44 662 PMID: 12668052

Jhamandas et al (2006) Facilitation of spinal mor. analgesia in normal and mor. tolerant animals by neuropeptide SF and related peptides. Peptides 27 953 PMID: 16515821

Gouarderes et al (2002) Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [125I]EYF as selective radioligands. Neurosci. 115 349

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Keywords: Neuropeptide SF (mouse, rat), Neuropeptide SF (mouse, rat) supplier, NPFF1, NPFF2, agonists, Neuropeptides, FF, AF, Receptors, FF/AF, acid, sensing, ion, channel, 3, ASIC3, NeuropeptideSF, (mouse, rat), npffr1, npffr2, ASIC, Neuropeptide, Miscellaneous/Non-selective, Opioids, 3647, Tocris Bioscience

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