Neuropeptide SF (mouse, rat)

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Cat.No. 3647 - Neuropeptide SF (mouse, rat) | Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe-NH2 | CAS No. 230960-31-3
Description: NPFF1 and NPFF2 agonist
Datasheet
Citations

Biological Activity

Neuropeptide FF receptor agonist (Ki values are 48.4 and 12.1 nM for NPFF1 and NPFF2, respectively). Potentiates the antinociceptive action of morphine in vivo and reverses the loss of morphine potency in tolerant animals. Also increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) (EC50 ~ 50 μM).

Technical Data

M. Wt 888.03
Formula C40H65N13O10
Sequence SLAAPQRF

(Modifications: Phe-8 = C-terminal amide)

Storage Store at -20°C
CAS Number 230960-31-3
PubChem ID 90488868
InChI Key OLOSAWFREOVGQW-CJKZIAQFSA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 20% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 888.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.13 mL 5.63 mL 11.26 mL
5 mM 0.23 mL 1.13 mL 2.25 mL
10 mM 0.11 mL 0.56 mL 1.13 mL
50 mM 0.02 mL 0.11 mL 0.23 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Deval et al (2003) Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability. Neuropharmacology 44 662 PMID: 12668052

Jhamandas et al (2006) Facilitation of spinal morphine analgesia in normal and morphine tolerant animals by neuropeptide SF and related peptides. Peptides 27 953 PMID: 16515821

Gouarderes et al (2002) Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [125I]EYF as selective radioligands. Neurosci. 115 349 PMID:


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Keywords: NPFF1 NPFF2 agonists Neuropeptides FF AF Receptors FF/AF acid sensing ion channel 3 ASIC3 NeuropeptideSF (mouse rat) npffr1 npffr2 ASIC Neuropeptide FF/AF Receptor Peptide

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