Neuropeptide AF (human)

Pricing Availability Delivery Time Qty
Cat.No. 1928 - Neuropeptide AF (human) | Ala-Gly-Glu-Gly-Leu-Asn-Ser-Gln-Phe-Trp-Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe-NH2 | CAS No. 192387-38-5
Description: Implicated in pain modulation, opioid function and metabolism
Alternative Names: NPAF, Neuropeptide NPAF (human FMRFamide-related)
Datasheet
Citations

Biological Activity

Endogenous antiopioid peptide, implicated in pain modulation and endocrine functions. May also regulate metabolism via stimulation of β-adrenoceptor expression in adipocytes.

Technical Data

M. Wt 1978.19
Formula C90H132N26O25
Sequence AGEGLNSQFWSLAAPQRF

(Modifications: Phe-18 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 192387-38-5
PubChem ID 90488726
InChI Key DYSIROANKWMSGC-KWFINLGMSA-N
Smiles [H]N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1978.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.51 mL 2.53 mL 5.06 mL
5 mM 0.1 mL 0.51 mL 1.01 mL
10 mM 0.05 mL 0.25 mL 0.51 mL
50 mM 0.01 mL 0.05 mL 0.1 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Elshourbagy et al (2000) Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J.Biol.Chem. 275 25965 PMID: 10851242

Lefrere et al (2002) Neuropeptide AF and FF modulation of adipocyte metabolism. J.Biol.Chem. 277 39169 PMID: 12149260

Vilim et al (1999) Gene for pain modulatory neuropeptide FF: induction in spinal cord by noxious stimuli. Mol.Pharmacol. 55 804 PMID: 10220558


If you know of a relevant reference for Neuropeptide AF (human), please let us know.

Keywords: Implicated pain modulation Anti-opioids neuropeptides FF AF NPFF Receptors NPAF Neuropeptide NPAF (human FMRFamide-related) Neuropeptide FF/AF Receptor Peptide

Citations for Neuropeptide AF (human)

Citations are publications that use Tocris products.

Currently there are no citations for Neuropeptide AF (human). Do you know of a great paper that uses Neuropeptide AF (human) from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Pathways for Neuropeptide AF (human)

Protocols

TODO: Add Protocols