Neuropeptide AF (human)

Pricing Availability   Qty
Cat.No. 1928 - Neuropeptide AF (human) | Ala-Gly-Glu-Gly-Leu-Asn-Ser-Gln-Phe-Trp-Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe-NH2 | CAS No. 192387-38-5
Description: Endogenous NPFF1 and NPFF2 agonist; antiopioid neuropeptide
Alternative Names: NPAF, Neuropeptide NPAF (human FMRFamide-related)
Datasheet
Citations
Reviews
Literature

Biological Activity

Endogenous antiopioid neuropeptide and agonist at NPFF1 and NPFF2 receptors. Implicated in pain modulation and endocrine functions. May also regulate metabolism via stimulation of β-adrenoceptor expression in adipocytes.

Technical Data

M. Wt 1978.19
Formula C90H132N26O25
Sequence AGEGLNSQFWSLAAPQRF

(Modifications: Phe-18 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 192387-38-5
PubChem ID 90488726
InChI Key DYSIROANKWMSGC-KWFINLGMSA-N
Smiles [H]N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Elshourbagy et al (2000) Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor. J.Biol.Chem. 275 25965 PMID: 10851242

Lefrere et al (2002) Neuropeptide AF and FF modulation of adipocyte metabolism. J.Biol.Chem. 277 39169 PMID: 12149260

Vilim et al (1999) Gene for pain modulatory neuropeptide FF: induction in spinal cord by noxious stimuli. Mol.Pharmacol. 55 804 PMID: 10220558


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Keywords: Neuropeptide AF (human), Neuropeptide AF (human) supplier, Implicated, pain, modulation, antiopioid, neuropeptides, FF, AF, NPFF, Receptors, NPFF1, NPFF2, endogenous, agonists, NPAF, Neuropeptide, (human, FMRFamide-related), Miscellaneous/Non-selective, Opioids, FF/AF, 1928, Tocris Bioscience

Citations for Neuropeptide AF (human)

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Literature in this Area

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