Neuromedin S (rat)

Pricing Availability   Qty
Cat.No. 3648 - Neuromedin S (rat) | Leu-Pro-Arg-Leu-Leu-His-Thr-Asp-Ser-Arg-Met-Ala-Thr-Ile-Asp-Phe-Pro-Lys-Lys-Asp-Pro-Thr-Thr-Ser-Leu-Gly-Arg-Pro-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2 | CAS No. 843782-19-4
Description: Potent, endogenous NMU1 and NMU2 agonist
Citations (1)
Literature (2)

Biological Activity for Neuromedin S (rat)

Neuromedin S (rat) is a potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Induces phase shifts in the circadian rhythm of locomotor activity following i.c.v. administration. Potent endogenous anorexigenic peptide.

Technical Data for Neuromedin S (rat)

M. Wt 4241.97
Formula C193H307N57O49S

(Modifications: Asn-36 = C-terminal amide)

Storage Store at -20°C
CAS Number 843782-19-4
PubChem ID 90488896
Smiles [H]N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Neuromedin S (rat)

Solubility Soluble to 0.50 mg/ml in 20% acetonitrile / water

Product Datasheets for Neuromedin S (rat)

References for Neuromedin S (rat)

References are publications that support the biological activity of the product.

Mori et al (2005) Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J. 24 325 PMID: 15635449

Ida et al (2005) Neuromedin S is a novel anorexigenic hormone. Endocrinology 146 4217 PMID: 15976061

Mitchell et al (2009) Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S. Br.J.Pharmacol. 158 87 PMID: 19519756

If you know of a relevant reference for Neuromedin S (rat), please let us know.

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View all Neuromedin U Receptor Agonists

Keywords: Neuromedin S (rat), Neuromedin S (rat) supplier, Potent, endogenous, NMU1, and, NMU2, agonists, Neuromedin, U, Receptors, NeuromedinS, (rat), circadian, rhythms, 3648, Tocris Bioscience

1 Citation for Neuromedin S (rat)

Citations are publications that use Tocris products. Selected citations for Neuromedin S (rat) include:

Sampson et al (2018) Small-Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models. Pharmacol Res Perspect 6 e00425 PMID: 30151213

Do you know of a great paper that uses Neuromedin S (rat) from Tocris? Please let us know.

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