Endogenous neurotensin-like neuropeptide, originally isolated from porcine spinal cord. Binds to neurotensin receptors (IC50 = 16.7 nM for inhibition of [Trp11]-NT binding to rat brain receptors). Regulates guinea pig intestinal smooth muscle contraction and produces hypotension in rats. Also induces hypothermia following central administration in rats in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.50 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 745.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.34 mL||6.7 mL||13.41 mL|
|5 mM||0.27 mL||1.34 mL||2.68 mL|
|10 mM||0.13 mL||0.67 mL||1.34 mL|
|50 mM||0.03 mL||0.13 mL||0.27 mL|
References are publications that support the biological activity of the product.
Checler et al (1986) Neuromedin N: high affinity interaction with neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur.J.Pharmacol. 126 239 PMID: 3019713
Dubuc et al (1988) Hypothermic effect of neuromedin N in mice and its potentiation by peptidase inhibitors. Eur.J.Pharmacol. 151 117 PMID: 3416919
Minamino et al (1984) Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord. Biochem.Biophys.Res.Commun. 122 542 PMID: 6547840
If you know of a relevant reference for Neuromedin N (rat, mouse, porcine, canine), please let us know.
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Keywords: Neuromedin N, Neuromedin N supplier, Neurotensin-like, peptide, NT, Receptors, Neurotensin, agonists, NeuromedinN, 1907, Tocris Bioscience
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.