Neuromedin N (rat, mouse, porcine, canine)

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Cat.No. 1907 - Neuromedin N | Lys-Ile-Pro-Tyr-Ile-Leu | CAS No. 92169-45-4
Description: Neurotensin-like peptide

Biological Activity

Endogenous neurotensin-like neuropeptide, originally isolated from porcine spinal cord. Binds to neurotensin receptors (IC50 = 16.7 nM for inhibition of [Trp11]-NT binding to rat brain receptors). Regulates guinea pig intestinal smooth muscle contraction and produces hypotension in rats. Also induces hypothermia following central administration in rats in vivo.

Technical Data

M. Wt 745.96
Formula C38H63N7O8
Sequence KIPYIL
Storage Desiccate at -20°C
CAS Number 92169-45-4
PubChem ID 9940301
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 0.50 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 745.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.34 mL 6.7 mL 13.41 mL
5 mM 0.27 mL 1.34 mL 2.68 mL
10 mM 0.13 mL 0.67 mL 1.34 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the biological activity of the product.

Checler et al (1986) Neuromedin N: high affinity interaction with neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur.J.Pharmacol. 126 239 PMID: 3019713

Dubuc et al (1988) Hypothermic effect of neuromedin N in mice and its potentiation by peptidase inhibitors. Eur.J.Pharmacol. 151 117 PMID: 3416919

Minamino et al (1984) Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord. Biochem.Biophys.Res.Commun. 122 542 PMID: 6547840

If you know of a relevant reference for Neuromedin N (rat, mouse, porcine, canine), please let us know.

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Keywords: Neuromedin N, Neuromedin N supplier, Neurotensin-like, peptide, NT, Receptors, Neurotensin, agonists, NeuromedinN, 1907, Tocris Bioscience

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