Endogenous neurotensin-like neuropeptide, originally isolated from porcine spinal cord. Binds to neurotensin receptors (IC50 = 16.7 nM for inhibition of [Trp11]-NT binding to rat brain receptors). Regulates guinea pig intestinal smooth muscle contraction and produces hypotension in rats. Also induces hypothermia following central administration in rats in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 0.50 mg/ml in water|
References are publications that support the biological activity of the product.
Checler et al (1986) Neuromedin N: high affinity interaction with neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur.J.Pharmacol. 126 239 PMID: 3019713
Dubuc et al (1988) Hypothermic effect of neuromedin N in mice and its potentiation by peptidase inhibitors. Eur.J.Pharmacol. 151 117 PMID: 3416919
Minamino et al (1984) Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord. Biochem.Biophys.Res.Commun. 122 542 PMID: 6547840
If you know of a relevant reference for Neuromedin N (rat, mouse, porcine, canine), please let us know.
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Keywords: Neuromedin N, Neuromedin N supplier, Neurotensin-like, peptide, NT, Receptors, Neurotensin, agonists, NeuromedinN, 1907, Tocris Bioscience
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.