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Mammalian bombesin-like neuropeptide; first isolated from pig spinal cord. Stimulates rat uterine smooth muscle contraction, and gastrin and somatostatin secretion in vitro. Increases blood pressure and pancreatic exocrine secretion in dogs in vivo.
(Modifications: Met-10 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Hosotani et al (1985) Effect of synthetic neuromedin C, a decapeptide of gastrin-releasing peptide (GRP[18-27]), on blood flow and exocrine secretion of the pancreas in dogs. Life Sci. 36 2429 PMID: 3892215
Madaus et al (1989) Effect of gastrin-releasing peptide (GRP1-27), neuromedin-C (GRP18-27), and neuromedin-B on gastrin and somatostatin secretion from the rat stomach. Z.Gastroenterol. 27 449 PMID: 2573979
Minamino et al (1984) Neuromedin C: a bombesin-like peptide identified in porcine spinal cord. Biochem.Biophys.Res.Commun. 119 14 PMID: 6546686
Keywords: Neuromedin C (porcine), Neuromedin C (porcine) supplier, Mammalian, bombesin-like, peptide, GRP-Preferring, Receptors, BB1, BB2, BB3, Gastrin-Releasing, Peptide-Preferring, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, NeuromedinC, (porcine), GRP, (18-27), 1890, Tocris Bioscience
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.