Neuromedin B (porcine)

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Cat.No. 1908 - Neuromedin B (porcine) | Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2 | CAS No. 87096-84-2
Description: Mammalian bombesin-like peptide
Datasheet
Citations
Reviews
Literature

Biological Activity

Mammalian bombesin-like peptide and endogenous ligand for the neuromedin B receptor (IC50 = 2 nM); first isolated from pig spinal cord. Regulates endocrine and exocrine secretion, smooth muscle contraction, blood pressure, feeding and cell growth.

Technical Data

M. Wt 1132.3
Formula C52H73N15O12S
Sequence GNLWATGHFM

(Modifications: Met-10 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 87096-84-2
PubChem ID 6324606
InChI Key YPFNACALNKVZNK-MFNIMNRCSA-N
Smiles [H]NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1132.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.88 mL 4.42 mL 8.83 mL
5 mM 0.18 mL 0.88 mL 1.77 mL
10 mM 0.09 mL 0.44 mL 0.88 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Minamino et al (1983) Neuromedin B: a novel bombesin-like peptide identified in porcine spinal cord. Biochem.Biophys.Res.Commun. 114 541 PMID: 6882442

Ohki-Hamazaki et al (2000) Neuromedin B. Prog.Neurobiol. 62 297 PMID: 10840151

Sainz et al (1998) Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor. J.Biol.Chem. 273 15927 PMID: 9632639


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