Mammalian bombesin-like peptide and endogenous ligand for the neuromedin B receptor (IC50 = 2 nM); first isolated from pig spinal cord. Regulates endocrine and exocrine secretion, smooth muscle contraction, blood pressure, feeding and cell growth.
(Modifications: Met-10 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1132.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.88 mL||4.42 mL||8.83 mL|
|5 mM||0.18 mL||0.88 mL||1.77 mL|
|10 mM||0.09 mL||0.44 mL||0.88 mL|
|50 mM||0.02 mL||0.09 mL||0.18 mL|
References are publications that support the products' biological activity.
Minamino et al (1983) Neuromedin B: a novel bombesin-like peptide identified in porcine spinal cord. Biochem.Biophys.Res.Commun. 114 541 PMID: 6882442
Ohki-Hamazaki et al (2000) Neuromedin B. Prog.Neurobiol. 62 297 PMID: 10840151
Sainz et al (1998) Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor. J.Biol.Chem. 273 15927 PMID: 9632639
If you know of a relevant reference for Neuromedin B (porcine), please let us know.
Keywords: Neuromedin B (porcine), supplier, Mammalian, bombesin-like, peptide, GRP-Preferring, Receptors, BB1, BB2, BB3, Gastrin-Releasing, Peptide-Preferring, NMB-Preferring, Neuromedin, B-Preferring, Bombesin, agonists, NeuromedinB, (porcine), Bombesin, Receptors, Bombesin, Receptors, Tocris Bioscience
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.