Home / Pharmacology / Other Pharmacology / Antivirals / Netilmicin sulfate

Netilmicin sulfate

Cat. No. 6339 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 6339 - Netilmicin sulfate | C21H41N5O7.2.5H2SO4 | CAS No. 56391-57-2
Description: Inhibits HIV-1 replication; also semisynthetic aminoglycoside antibiotic
Chemical Name: O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N1-ethyl-D-streptamine sestersulfate
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Binds the transactivation response element (TAR) of HIV-1 (Kd = 1.35 μM) and inhibits its interaction with Tat. Exhibits >35-fold selectivity for HIV-1 TAR over HIV-2 TAR or A-site and RRE RNA. Inhibits Tat-mediated HIV-1 activation and replication in T-cells in vitro. Also semisynthetic aminoglycoside antibiotic.

Technical Data

M. Wt 720.78
Formula C21H41N5O7.2.5H2SO4
Storage Desiccate at RT
CAS Number 56391-57-2
PubChem ID 62115
InChI Key AGFWIZQEWFGATK-UNZHCMSXSA-N
Smiles OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.[H][C@@]1(OC(CN)=CC[C@H]1N)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@]3(OC[C@](O)([C@@H]([C@H]3O)NC)C)[H])NCC)N.[H][C@@]4(OC(CN)=CC[C@H]4N)O[C@@H]5[C@H](C[C@H]([C@@H]([C@H]5O)O[C@]6(OC[C@](O)([C@@H]([C@H]6O)NC)C)[H])NCC)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 72.08 100

Preparing Stock Solutions

The following data is based on the product molecular weight 720.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.39 mL 6.94 mL 13.87 mL
5 mM 0.28 mL 1.39 mL 2.77 mL
10 mM 0.14 mL 0.69 mL 1.39 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Stelzer et al (2011) Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble. Nat.Chem.Biol. 7 553 PMID: 21706033

Connelly et al (2016) The emerging role of RNA as a therapeutic target for small molecules. Cell.Chem.Biol. 23 1077 PMID: 27593111

If you know of a relevant reference for Netilmicin sulfate, please let us know.

View Related Products by Target

Keywords: Netilmicin sulfate, Netilmicin sulfate supplier, HIV-1, transactivation, response, element, TAR, Tat, inhibitors, inhibits, semisynthetic, aminoglycoside, antibiotic, Antibiotics, Antivirals, Other, Transcription, Factors, 6339, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Netilmicin sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Netilmicin sulfate

Citations are publications that use Tocris products.

Currently there are no citations for Netilmicin sulfate. Do you know of a great paper that uses Netilmicin sulfate from Tocris? Please let us know.

Reviews for Netilmicin sulfate

There are currently no reviews for this product. Be the first to review Netilmicin sulfate and earn rewards!

Have you used Netilmicin sulfate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Coronavrius Research Brochure

Coronavrius Research Brochure eBook

COVID-19 is a potentially fatal form of pneumonia that emerged in China in 2019. It is caused by a newly identified coronavirus termed SARS-CoV-2. This brochure provides an overview of our knowledge of the virus and highlights products available from Bio-Techne to enable research into finding a treatment, including:

  • Antibodies, Recombinant Proteins, Small Molecules
  • Immunoassays
  • Cell Isolation and Identification Kits
  • Tocriscreen Compound Libraries
  • RNAscopeTM Assays
  • Instrumentation