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Submit ReviewNetilmicin sulfate
Discontinued Product
Netilmicin sulfate (Cat. No. 6339) has been withdrawn from sale for commercial reasons.
Description: Inhibits HIV-1 viral replication by blocking TAR-tat interaction
Chemical Name: O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N1-ethyl-D-streptamine sestersulfate
Biological Activity
Binds the transactivation response element (TAR) of HIV-1 (Kd = 1.35 μM) and inhibits its interaction with Tat. Exhibits >35-fold selectivity for HIV-1 TAR over HIV-2 TAR or A-site and RRE RNA. Inhibits Tat-mediated HIV-1 activation and replication in T-cells in vitro. Also semisynthetic aminoglycoside antibiotic.
Technical Data
| M. Wt | 720.78 |
| Formula | C21H41N5O7.2.5H2SO4 |
| Storage | Desiccate at RT |
| CAS Number | 56391-57-2 |
| PubChem ID | 62115 |
| InChI Key | AGFWIZQEWFGATK-UNZHCMSXSA-N |
| Smiles | OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.[H][C@@]1(OC(CN)=CC[C@H]1N)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@]3(OC[C@](O)([C@@H]([C@H]3O)NC)C)[H])NCC)N.[H][C@@]4(OC(CN)=CC[C@H]4N)O[C@@H]5[C@H](C[C@H]([C@@H]([C@H]5O)O[C@]6(OC[C@](O)([C@@H]([C@H]6O)NC)C)[H])NCC)N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Stelzer et al (2011) Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble. Nat.Chem.Biol. 7 553 PMID: 21706033
Connelly et al (2016) The emerging role of RNA as a therapeutic target for small molecules. Cell.Chem.Biol. 23 1077 PMID: 27593111
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Keywords: Netilmicin sulfate, Netilmicin sulfate supplier, HIV-1, transactivation, response, element, TAR, Tat, inhibitors, inhibits, semisynthetic, aminoglycoside, antibiotic, Antibiotics, Other, Transcription, Factors, HIV, 6339, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Netilmicin sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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