Netilmicin sulfate

Discontinued Product

Netilmicin sulfate (Cat. No. 6339) has been withdrawn from sale for commercial reasons.
Cat.No. 6339 - Netilmicin sulfate | C21H41N5O7.2.5H2SO4 | CAS No. 56391-57-2
Description: Inhibits HIV-1 viral replication by blocking TAR-tat interaction
Chemical Name: O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N1-ethyl-D-streptamine sestersulfate
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Binds the transactivation response element (TAR) of HIV-1 (Kd = 1.35 μM) and inhibits its interaction with Tat. Exhibits >35-fold selectivity for HIV-1 TAR over HIV-2 TAR or A-site and RRE RNA. Inhibits Tat-mediated HIV-1 activation and replication in T-cells in vitro. Also semisynthetic aminoglycoside antibiotic.

Technical Data

M. Wt 720.78
Formula C21H41N5O7.2.5H2SO4
Storage Desiccate at RT
CAS Number 56391-57-2
PubChem ID 62115
InChI Key AGFWIZQEWFGATK-UNZHCMSXSA-N
Smiles OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.[H][C@@]1(OC(CN)=CC[C@H]1N)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@]3(OC[C@](O)([C@@H]([C@H]3O)NC)C)[H])NCC)N.[H][C@@]4(OC(CN)=CC[C@H]4N)O[C@@H]5[C@H](C[C@H]([C@@H]([C@H]5O)O[C@]6(OC[C@](O)([C@@H]([C@H]6O)NC)C)[H])NCC)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Stelzer et al (2011) Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble. Nat.Chem.Biol. 7 553 PMID: 21706033

Connelly et al (2016) The emerging role of RNA as a therapeutic target for small molecules. Cell.Chem.Biol. 23 1077 PMID: 27593111

Keywords: Netilmicin sulfate, Netilmicin sulfate supplier, HIV-1, transactivation, response, element, TAR, Tat, inhibitors, inhibits, semisynthetic, aminoglycoside, antibiotic, Antibiotics, Other, Transcription, Factors, HIV, 6339, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Netilmicin sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Netilmicin sulfate

Citations are publications that use Tocris products.

Currently there are no citations for Netilmicin sulfate.

Reviews for Netilmicin sulfate

There are currently no reviews for this product. Be the first to review Netilmicin sulfate and earn rewards!

Have you used Netilmicin sulfate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells