Binds the transactivation response element (TAR) of HIV-1 (Kd = 1.35 μM) and inhibits its interaction with Tat. Exhibits >35-fold selectivity for HIV-1 TAR over HIV-2 TAR or A-site and RRE RNA. Inhibits Tat-mediated HIV-1 activation and replication in T-cells in vitro. Also semisynthetic aminoglycoside antibiotic.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 720.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.39 mL||6.94 mL||13.87 mL|
|5 mM||0.28 mL||1.39 mL||2.77 mL|
|10 mM||0.14 mL||0.69 mL||1.39 mL|
|50 mM||0.03 mL||0.14 mL||0.28 mL|
References are publications that support the products' biological activity.
Stelzer et al (2011) Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble. Nat.Chem.Biol. 7 553 PMID: 21706033
Connelly et al (2016) The emerging role of RNA as a therapeutic target for small molecules. Cell.Chem.Biol. 23 1077 PMID: 27593111
If you know of a relevant reference for Netilmicin sulfate, please let us know.
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Keywords: Netilmicin sulfate, supplier, HIV-1, transactivation, response, element, TAR, Tat, HIV-1, inhibitors, inhibits, semisynthetic, aminoglycoside, antibiotic, Antibiotics, Antivirals, Other, Transcription, Factors, Antivirals, Tocris Bioscience
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