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Netilmicin sulfate

Cat. No. 6339 Submit a Review Datasheet / COA / SDS

Discontinued Product

Netilmicin sulfate (Cat. No. 6339) has been withdrawn from sale for commercial reasons.
Cat.No. 6339 - Netilmicin sulfate | C21H41N5O7.2.5H2SO4 | CAS No. 56391-57-2
Description: Inhibits HIV-1 viral replication by blocking TAR-tat interaction
Chemical Name: O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N1-ethyl-D-streptamine sestersulfate
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Datasheets References

Biological Activity

Binds the transactivation response element (TAR) of HIV-1 (Kd = 1.35 μM) and inhibits its interaction with Tat. Exhibits >35-fold selectivity for HIV-1 TAR over HIV-2 TAR or A-site and RRE RNA. Inhibits Tat-mediated HIV-1 activation and replication in T-cells in vitro. Also semisynthetic aminoglycoside antibiotic.

Technical Data

M. Wt 720.78
Formula C21H41N5O7.2.5H2SO4
Storage Desiccate at RT
CAS Number 56391-57-2
PubChem ID 62115
InChI Key AGFWIZQEWFGATK-UNZHCMSXSA-N
Smiles OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.[H][C@@]1(OC(CN)=CC[C@H]1N)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@]3(OC[C@](O)([C@@H]([C@H]3O)NC)C)[H])NCC)N.[H][C@@]4(OC(CN)=CC[C@H]4N)O[C@@H]5[C@H](C[C@H]([C@@H]([C@H]5O)O[C@]6(OC[C@](O)([C@@H]([C@H]6O)NC)C)[H])NCC)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Stelzer et al (2011) Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble. Nat.Chem.Biol. 7 553 PMID: 21706033

Connelly et al (2016) The emerging role of RNA as a therapeutic target for small molecules. Cell.Chem.Biol. 23 1077 PMID: 27593111

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Keywords: Netilmicin sulfate, Netilmicin sulfate supplier, HIV-1, transactivation, response, element, TAR, Tat, inhibitors, inhibits, semisynthetic, aminoglycoside, antibiotic, Antibiotics, Other, Transcription, Factors, HIV, 6339, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Netilmicin sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Netilmicin sulfate

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