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Biological Activity for NCL 00017509
NCL 00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC50 = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo.
Technical Data for NCL 00017509
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for NCL 00017509
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for NCL 00017509
The following data is based on the product molecular weight 292.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.42 mL||17.11 mL||34.21 mL|
|5 mM||0.68 mL||3.42 mL||6.84 mL|
|10 mM||0.34 mL||1.71 mL||3.42 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
References for NCL 00017509
References are publications that support the biological activity of the product.
Lebraud et al (2014) Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles. Org.Biomol.Chem. 12 141 PMID: 24213855
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Keywords: NCL 00017509, NCL 00017509 supplier, NCL00017509, NIMA, related, kinase, 2, NEK2, inhibitors, inhibits, mitotic, delay, Nek2, Kinase, 5150, Tocris Bioscience
Citations for NCL 00017509
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Literature in this Area
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