NCL 00017509

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Description: Potent and reversible NIMA related kinase 2 (Nek2) inhibitor
Chemical Name: 3-[(6-Ethynyl-9H-purin-2-yl)amino]benzeneacetamide
Purity: ≥97% (HPLC)
Citations (1)
Literature (4)

Biological Activity for NCL 00017509

NCL 00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC50 = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo. In mice bearing pancreatic tumors, NCL 00017509 decreases PD-L1 expression and induces an anticancer immune response.

Technical Data for NCL 00017509

M. Wt 292.3
Formula C15H12N6O
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1507367-00-1
PubChem ID 56944360
Smiles C#CC1=C2C(NC=N2)=NC(NC3=CC=CC(CC(N)=O)=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NCL 00017509

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.23 100

Preparing Stock Solutions for NCL 00017509

The following data is based on the product molecular weight 292.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.11 mL 34.21 mL
5 mM 0.68 mL 3.42 mL 6.84 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References for NCL 00017509

References are publications that support the biological activity of the product.

Lebraud et al (2014) Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles. Org.Biomol.Chem. 12 141 PMID: 24213855

Zhang et al (2021) NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1. Nat.Commun. 12 4536 PMID: 34315872

If you know of a relevant reference for NCL 00017509, please let us know.

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Keywords: NCL 00017509, NCL 00017509 supplier, NCL00017509, NIMA, related, kinase, 2, NEK2, inhibitors, inhibits, mitotic, delay, Nek2, Kinase, 5150, Tocris Bioscience

1 Citation for NCL 00017509

Citations are publications that use Tocris products. Selected citations for NCL 00017509 include:

Zhang et al (2021) NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1. Nat Commun. 12 4536 PMID: 34315872

Do you know of a great paper that uses NCL 00017509 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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Cell Cycle & DNA Damage Repair Poster

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Epigenetics in Cancer Poster

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