NBI 27914 hydrochloride

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Cat.No. 1591 - NBI 27914 hydrochloride | C18H20Cl4N4.HCl | CAS No. 1215766-76-9
Description: Selective non-peptide CRF1 antagonist
Chemical Name: 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride
Purity: ≥99% (HPLC)
Citations (12)
Literature (3)

Biological Activity for NBI 27914 hydrochloride

NBI 27914 hydrochloride is a selective, non-peptide corticotropin-releasing factor1 (CRF1) receptor antagonist (Ki = 1.7 nM); has no activity at CRF2 receptors. Blocks behavioral seizures in vivo.

Compound Libraries for NBI 27914 hydrochloride

NBI 27914 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NBI 27914 hydrochloride

M. Wt 470.66
Formula C18H20Cl4N4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1215766-76-9
PubChem ID 45073446
Smiles Cl.CCCN(CC1CC1)C1=C(Cl)C(NC2=C(Cl)C=C(Cl)C=C2Cl)=NC(C)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NBI 27914 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 43.42 100
DMSO 43.42 100

Preparing Stock Solutions for NBI 27914 hydrochloride

The following data is based on the product molecular weight 470.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.62 mL 21.25 mL
5 mM 0.42 mL 2.12 mL 4.25 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets for NBI 27914 hydrochloride

Certificate of Analysis / Product Datasheet
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References for NBI 27914 hydrochloride

References are publications that support the biological activity of the product.

Baram et al (1997) The CRF1 receptor mediates the excitatory actions of cortico. releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res. 770 89 PMID: 9372207

Chen et al (1996) Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists. J.Med.Chem. 39 4358 PMID: 8893829

McCarthy et al (1999) Recent advances with the CRF1 receptor: design of small molecule inhibitors, receptor subtypes and clinical indications. Curr.Pharm.Des. 5 289 PMID: 10213797

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12 Citations for NBI 27914 hydrochloride

Citations are publications that use Tocris products. Selected citations for NBI 27914 hydrochloride include:

Silberman and Winder (2013) Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala. Neuropharmacology 70 316 PMID: 23470280

Delawary et al (2010) NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala. Mol Brain 3 37 PMID: 21118530

Liu et al (2010) Differential actions of urocortins on neurons of the myenteric division of the enteric nervous system in guinea pig distal colon. Br J Pharmacol 159 222 PMID: 20002096

Rajbhandari et al (2015) Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala NE Systems that Promote PTSD-Like Startle Abnormalities. J Neurosci 35 14270 PMID: 26490866

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Literature in this Area

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