NBD 556

Discontinued Product

NBD 556 (Cat. No. 5811) has been withdrawn from sale for commercial reasons.
Cat.No. 5811 - NBD 556 | C17H24ClN3O2 | CAS No. 333353-44-9
Description: Blocks HIV-1 viral cell entry; CD4 mimetic
Chemical Name: N1-(4-Chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)ethanediamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity

CD4 mimetic (IC50 values are in low micromolar range, dependent on cell type and HIV strain). Recognizes and induces structural changes in HIV-1 envelope protein gp120, analogous to CD4 binding. Inhibits HIV-1 cell entry in CXCR4 and CCR5 expressing cell lines, by blocking virus-cell and cell-cell fusion.

Technical Data

M. Wt 337.84
Formula C17H24ClN3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 333353-44-9
PubChem ID 1570601
InChI Key ZKXLQCIOURANAD-UHFFFAOYSA-N
Smiles CC1(CC(NC(C(NC2=CC=C(C=C2)Cl)=O)=O)CC(C)(N1)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Zhao et al (2005) Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4. Virology 339 213 PMID: 15996703

Kwon et al (2012) Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc.Natl.Acad.Sci.U.S.A. 109 5663 PMID: 22451932

Dogo-Isonagie et al (2012) Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. J.Biol.Chem. 287 15076 PMID: 22403408

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