NBD 556
Biological Activity
CD4 mimetic (IC50 values are in low micromolar range, dependent on cell type and HIV strain). Recognizes and induces structural changes in HIV-1 envelope protein gp120, analogous to CD4 binding. Inhibits HIV-1 cell entry in CXCR4 and CCR5 expressing cell lines, by blocking virus-cell and cell-cell fusion.
Technical Data
| M. Wt | 337.84 |
| Formula | C17H24ClN3O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 333353-44-9 |
| PubChem ID | 1570601 |
| InChI Key | ZKXLQCIOURANAD-UHFFFAOYSA-N |
| Smiles | CC1(CC(NC(C(NC2=CC=C(C=C2)Cl)=O)=O)CC(C)(N1)C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.78 | 100 | |
| ethanol | 6.76 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 337.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.8 mL | 29.6 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.92 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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References
References are publications that support the products' biological activity.
Zhao et al (2005) Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4. Virology 339 213 PMID: 15996703
Kwon et al (2012) Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc.Natl.Acad.Sci.U.S.A. 109 5663 PMID: 22451932
Dogo-Isonagie et al (2012) Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. J.Biol.Chem. 287 15076 PMID: 22403408
If you know of a relevant reference for NBD 556, please let us know.
View Related Products by Target
Keywords: NBD556 CD4 mimetic HIV entry blockers gp120 envelope proteins Antivirals
Citations for NBD 556
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