NBD 556

Pricing Availability   Qty
Cat.No. 5811 - NBD 556 | C17H24ClN3O2 | CAS No. 333353-44-9
Description: CD4 mimetic; blocks HIV-1 cell entry
Chemical Name: N1-(4-Chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)ethanediamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

CD4 mimetic (IC50 values are in low micromolar range, dependent on cell type and HIV strain). Recognizes and induces structural changes in HIV-1 envelope protein gp120, analogous to CD4 binding. Inhibits HIV-1 cell entry in CXCR4 and CCR5 expressing cell lines, by blocking virus-cell and cell-cell fusion.

Technical Data

M. Wt 337.84
Formula C17H24ClN3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 333353-44-9
PubChem ID 1570601
InChI Key ZKXLQCIOURANAD-UHFFFAOYSA-N
Smiles CC1(CC(NC(C(NC2=CC=C(C=C2)Cl)=O)=O)CC(C)(N1)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.78 100
ethanol 6.76 20

Preparing Stock Solutions

The following data is based on the product molecular weight 337.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.8 mL 29.6 mL
5 mM 0.59 mL 2.96 mL 5.92 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Zhao et al (2005) Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4. Virology 339 213 PMID: 15996703

Kwon et al (2012) Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc.Natl.Acad.Sci.U.S.A. 109 5663 PMID: 22451932

Dogo-Isonagie et al (2012) Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1. J.Biol.Chem. 287 15076 PMID: 22403408


If you know of a relevant reference for NBD 556, please let us know.

View Related Products by Target

Keywords: NBD 556, NBD 556 supplier, NBD556, CD4, mimetic, HIV, entry, blockers, gp120, envelope, proteins, Antivirals, 5811, Tocris Bioscience

Citations for NBD 556

Citations are publications that use Tocris products.

Currently there are no citations for NBD 556. Do you know of a great paper that uses NBD 556 from Tocris? Please let us know.

Reviews for NBD 556

There are currently no reviews for this product. Be the first to review NBD 556 and earn rewards!

Have you used NBD 556?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation