NAN-190 hydrobromide

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Cat.No. 0553 - NAN-190 hydrobromide | C23H27N3O3.HBr | CAS No. 115338-32-4
Description: 5-HT1A antagonist
Chemical Name: 1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine hydrobromide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

5-HT1A antagonist.

Technical Data

M. Wt 474.4
Formula C23H27N3O3.HBr
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 115338-32-4
PubChem ID 107966
InChI Key AXRUEPFPTQYHQD-UHFFFAOYSA-N
Smiles Br.COC1=C(C=CC=C1)N1CCN(CCCCN2C(=O)C3=CC=CC=C3C2=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.74 10

Preparing Stock Solutions

The following data is based on the product molecular weight 474.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.08 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Douris (1992) Effects of the putative 5-HT1A receptor antagonist NAN-190 on free feeding and on feeding induced by the 5-HT1A receptor agonist 8-OH-DPAT in the rat. Eur.J.Pharmacol. 219 105 PMID: 1397037

Glennon et al (1988) Arylpiperazine derivatives as high affinity 5-HT1A serotonin ligands. J.Med.Chem. 31 1968 PMID: 3172131

Williams and Glennon (1988) NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Eur.J.Pharmacol. 154 339 PMID: 2976673


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Keywords: NAN-190 hydrobromide, supplier, 5-HT1A, antagonists, Serotonin, Receptors, 5-HT1, NAN190, 5-HT1A, Receptors, Tocris Bioscience

2 Citations for NAN-190 hydrobromide

Citations are publications that use Tocris products. Selected citations for NAN-190 hydrobromide include:

Demarque and (2010) Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior. Neuron 67 321 PMID: 20670838

Pagano et al (2008) Gαo/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways. Physiol Behav 20 1190 PMID: 18407463


Do you know of a great paper that uses NAN-190 hydrobromide from Tocris? If so please let us know.

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