Naloxone 3-glucuronide carbonic acid salt

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Cat.No. 5684 - Naloxone 3-glucuronide carbonic acid salt | C25H29NO10.H2CO3
Description: Naloxone conjugate
Chemical Name: (5α)-4,5-Epoxy-14-hydroxy-6-oxo-17-(2-propenyl)morphinan-3-yl β-D-glucopyranosiduronic acid carbonic acid salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Naloxone conjugate. Following oral administration induces delayed diarrhea, as well as milder and delayed withdrawal behavior and tail skin temperature (TST) response compared with naloxone in morphine-dependent rats.

Technical Data

M. Wt 565.52
Formula C25H29NO10.H2CO3
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 121513881
InChI Key JWCWXAGEJDGZRX-IDUKCLALSA-N
Smiles O=C(O)O.O=C3[C@H]5[C@]26C1=C(O5)C(OC4OC(C(O)=O)C(O)C(O)C4O)=CC=C1C[C@@H](N(CC6)CC=C)[C@@](O)2CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.55 100
water 56.55 100

Preparing Stock Solutions

The following data is based on the product molecular weight 565.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.84 mL 17.68 mL
5 mM 0.35 mL 1.77 mL 3.54 mL
10 mM 0.18 mL 0.88 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Simpkins et al (1988) Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates. J.Pharmacol.Exp.Ther. 244 195 PMID: 3335997


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View Related Products by Target

Keywords: constipation opioids diarrhea narcotics glucuronide conjugates TST tail skin temperature Miscellaneous/Non-selective Opioids

Citations for Naloxone 3-glucuronide carbonic acid salt

Citations are publications that use Tocris products.

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