Naloxone 3-glucuronide carbonic acid salt
Naloxone conjugate. Following oral administration induces delayed diarrhea, as well as milder and delayed withdrawal behavior and tail skin temperature (TST) response compared with naloxone in morphine-dependent rats.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 565.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.77 mL||8.84 mL||17.68 mL|
|5 mM||0.35 mL||1.77 mL||3.54 mL|
|10 mM||0.18 mL||0.88 mL||1.77 mL|
|50 mM||0.04 mL||0.18 mL||0.35 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Simpkins et al (1988) Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates. J.Pharmacol.Exp.Ther. 244 195 PMID: 3335997
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Keywords: constipation opioids diarrhea narcotics glucuronide conjugates TST tail skin temperature Miscellaneous/Non-selective Opioids
Citations for Naloxone 3-glucuronide carbonic acid salt
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