Naloxone 3-glucuronide carbonic acid salt

Discontinued Product

Naloxone 3-glucuronide carbonic acid salt (Cat. No. 5684) has been withdrawn from sale for commercial reasons.
Description: Naloxone conjugate
Chemical Name: (5α)-4,5-Epoxy-14-hydroxy-6-oxo-17-(2-propenyl)morphinan-3-yl β-D-glucopyranosiduronic acid carbonic acid salt
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity

Naloxone 3-glucuronide carbonic acid salt is a Naloxone conjugate. Following oral administration induces delayed diarrhea, as well as milder and delayed withdrawal behavior and tail skin temperature (TST) response compared with naloxone in morphine-dependent rats.

Technical Data

M. Wt 565.52
Formula C25H29NO10.H2CO3
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 121513881
Smiles O=C(O)O.O=C3[C@H]5[C@]26C1=C(O5)C(OC4OC(C(O)=O)C(O)C(O)C4O)=CC=C1C[C@@H](N(CC6)CC=C)[C@@](O)2CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.


References are publications that support the biological activity of the product.

Simpkins et al (1988) Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates. J.Pharmacol.Exp.Ther. 244 195 PMID: 3335997

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Keywords: Naloxone 3-glucuronide carbonic acid salt, Naloxone 3-glucuronide carbonic acid salt supplier, constipation, opioids, diarrhea, narcotics, glucuronide, conjugates, TST, tail, skin, temperature, Miscellaneous/Non-selective, Opioids, 5684, Tocris Bioscience

Citations for Naloxone 3-glucuronide carbonic acid salt

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Currently there are no citations for Naloxone 3-glucuronide carbonic acid salt.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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