Naloxone 3-glucuronide carbonic acid salt

Pricing Availability   Qty
Cat.No. 5684 - Naloxone 3-glucuronide carbonic acid salt | C25H29NO10.H2CO3
Description: Naloxone conjugate
Chemical Name: (5α)-4,5-Epoxy-14-hydroxy-6-oxo-17-(2-propenyl)morphinan-3-yl β-D-glucopyranosiduronic acid carbonic acid salt
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity

Naloxone conjugate. Following oral administration induces delayed diarrhea, as well as milder and delayed withdrawal behavior and tail skin temperature (TST) response compared with naloxone in morphine-dependent rats.

Technical Data

M. Wt 565.52
Formula C25H29NO10.H2CO3
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 121513881
Smiles O=C(O)O.O=C3[C@H]5[C@]26C1=C(O5)C(OC4OC(C(O)=O)C(O)C(O)C4O)=CC=C1C[C@@H](N(CC6)CC=C)[C@@](O)2CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 56.55 100
DMSO 56.55 100

Preparing Stock Solutions

The following data is based on the product molecular weight 565.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.77 mL 8.84 mL 17.68 mL
5 mM 0.35 mL 1.77 mL 3.54 mL
10 mM 0.18 mL 0.88 mL 1.77 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.


References are publications that support the biological activity of the product.

Simpkins et al (1988) Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates. J.Pharmacol.Exp.Ther. 244 195 PMID: 3335997

If you know of a relevant reference for Naloxone 3-glucuronide carbonic acid salt, please let us know.

View Related Products by Target

Keywords: Naloxone 3-glucuronide carbonic acid salt, Naloxone 3-glucuronide carbonic acid salt supplier, constipation, opioids, diarrhea, narcotics, glucuronide, conjugates, TST, tail, skin, temperature, Miscellaneous/Non-selective, Opioids, 5684, Tocris Bioscience

Citations for Naloxone 3-glucuronide carbonic acid salt

Citations are publications that use Tocris products.

Currently there are no citations for Naloxone 3-glucuronide carbonic acid salt. Do you know of a great paper that uses Naloxone 3-glucuronide carbonic acid salt from Tocris? Please let us know.

Reviews for Naloxone 3-glucuronide carbonic acid salt

There are currently no reviews for this product. Be the first to review Naloxone 3-glucuronide carbonic acid salt and earn rewards!

Have you used Naloxone 3-glucuronide carbonic acid salt?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.


Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.


Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.