Nafarelin

Pricing Availability   Qty
Cat.No. 2544 - Nafarelin | Glp-His-Trp-Ser-Tyr-D-2NaI-Leu-Arg-Pro-Gly-NH2 | CAS No. 76932-56-4
Description: GnRH receptor agonist
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Synthetic gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Repeated administration causes desensitization of pituitary GnRH receptors resulting in inhibition of gonadotropin release and decreased steroid hormone synthesis. Induces atrophy and regression of experimentally induced endometriosis in rat and shrinks hypertrophic tissue in benign prostatic hyperplasia.

Technical Data

M. Wt 1322
Formula C66H83N17O13
Sequence XEHWSYXLRPG

(Modifications: X-1 = Glp, X-2 = 2-Nal, Gly-10 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 76932-56-4
PubChem ID 25077405
InChI Key RWHUEXWOYVBUCI-ITQXDASVSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Chrisp and Goa (1990) Nafarelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical potential in sex hormone-related conditions. Drugs 39 523 PMID: 2140979

Letassy et al (1990) Nafarelin acetate: a gonadotrophin-releasing hormone agonist for the treatment of endometriosis. DICP 24 1204 PMID: 2151003

Mizutani et al (1995) Effect of gonadotrophin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat. Int.J.Fertil.Menopausal Stud. 40 106 PMID: 7599657


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Keywords: Nafarelin, Nafarelin supplier, GnRH, receptor, agonists, Receptors, Gonadotrophin-Releasing, Hormone, gonadotropin, 2544, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Nafarelin acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Nafarelin

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