Nafarelin

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Cat.No. 2544 - Nafarelin | Glp-His-Trp-Ser-Tyr-D-2NaI-Leu-Arg-Pro-Gly-NH2 | CAS No. 76932-56-4
Description: GnRH receptor agonist
Datasheet
Citations
Literature

Biological Activity

Synthetic gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Repeated administration causes desensitization of pituitary GnRH receptors resulting in inhibition of gonadotropin release and decreased steroid hormone synthesis. Induces atrophy and regression of experimentally induced endometriosis in rat and shrinks hypertrophic tissue in benign prostatic hyperplasia.

Technical Data

M. Wt 1322
Formula C66H83N17O13
Sequence XEHWSYXLRPG

(Modifications: X-1 = Glp, X-2 = 2-Nal, Gly-10 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 76932-56-4
PubChem ID 25077405
InChI Key RWHUEXWOYVBUCI-ITQXDASVSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1322. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.76 mL 3.78 mL 7.56 mL
5 mM 0.15 mL 0.76 mL 1.51 mL
10 mM 0.08 mL 0.38 mL 0.76 mL
50 mM 0.02 mL 0.08 mL 0.15 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chrisp and Goa (1990) Nafarelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical potential in sex hormone-related conditions. Drugs 39 523 PMID: 2140979

Letassy et al (1990) Nafarelin acetate: a gonadotrophin-releasing hormone agonist for the treatment of endometriosis. DICP 24 1204 PMID: 2151003

Mizutani et al (1995) Effect of gonadotrophin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat. Int.J.Fertil.Menopausal Stud. 40 106 PMID: 7599657


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Keywords: GnRH receptor agonists Receptors Gonadotrophin-Releasing Hormone gonadotropin Gonadotrophin-Releasing Hormone Receptors

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Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

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  • Secretin-like Receptors
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Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing

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