NAADP tetrasodium salt

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Cat.No. 3905 - NAADP tetrasodium salt | C21H23N6Na4O18P3
Description: Ca2+ mobilizing agent
Alternative Names: NAADP
Chemical Name: Nicotinic acid adenine dinucleotide phosphate tetrasodium salt
Purity: ≥98% (HPLC)
Citations (3)

Biological Activity

Ca2+ mobilizing agent. Initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca2+ from acidic organelles.

Technical Data

M. Wt 832.32
Formula C21H23N6Na4O18P3
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 90488897
Smiles [Na+].[Na+].[Na+].[Na+].NC1=C2N=CN([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)[N+]4=CC(=CC=C4)C([O-])=O)[C@@H](O)[C@H]3OP([O-])([O-])=O)C2=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 41.62 50

Preparing Stock Solutions

The following data is based on the product molecular weight 832.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.4 mL 12.01 mL 24.03 mL
2.5 mM 0.48 mL 2.4 mL 4.81 mL
5 mM 0.24 mL 1.2 mL 2.4 mL
25 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Calcraft et al (2009) NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459 596 PMID: 19387438

Dammerman et al (2009) NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist. Proc.Natl.Acad.Sci. 106 10678

Galion (2006) NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores. Biochem.Soc.Transactions 34 922

If you know of a relevant reference for NAADP tetrasodium salt, please let us know.

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3 Citations for NAADP tetrasodium salt

Citations are publications that use Tocris products. Selected citations for NAADP tetrasodium salt include:

Hadi et al (2018) Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells. Nat Commun 9 5022 PMID: 30479344

Ruas et al (2015) Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. Am J Physiol Gastrointest Liver Physiol NULL PMID: 25872774

Wang et al (2012) TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell 151 372 PMID: 23063126

Do you know of a great paper that uses NAADP tetrasodium salt from Tocris? Please let us know.

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