N,N-Dimethylsphingosine

Pricing Availability Delivery Time Qty
Cat.No. 4640 - N,N-Dimethylsphingosine | C20H41NO2 | CAS No. 119567-63-4
Description: Sphingosine kinase inhibitor
Chemical Name: (2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Competitive sphingosine kinase (SphK) inhibitor. Exhibits inhibitory activity in platelets and in cytosolic extracts from U937, Swiss 3T3 and PC12 cells. Selectively inhibits sphingosine phosphorylation; does not inhibit N-acylation, and displays no inhibitory effect on protein kinase C at concentrations that inhibit SphK. Increases the release of IL-1β and MCP-1 in cultured astrocytes; thought to mediate mechanical allodynia via this mechanism.

Technical Data

M. Wt 327.55
Formula C20H41NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 119567-63-4
PubChem ID 5282309
InChI Key YRXOQXUDKDCXME-YIVRLKKSSA-N
Smiles O[C@@H]([C@H](CO)N(C)C)/C=C/CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.83 30

Preparing Stock Solutions

The following data is based on the product molecular weight 327.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.26 mL 30.53 mL
5 mM 0.61 mL 3.05 mL 6.11 mL
10 mM 0.31 mL 1.53 mL 3.05 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Patti et al (2012) Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin. Nat.Chem.Biol. 8 232 PMID: 22267119

Edsall et al (1998) N,N-dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry 37 12892 PMID: 9737868

Yatomi et al (1996) N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. Biochemistry 35 626 PMID: 8555236


If you know of a relevant reference for N,N-Dimethylsphingosine, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Sphingosine Kinase Inhibitors

Keywords: N,N-Dimethylsphingosine, supplier, sphingosine, kinases, SphK, inhibitors, inhibits, neuropathic, pain, Sphingosine, Kinase, Sphingosine, Kinase, Tocris Bioscience

Citations for N,N-Dimethylsphingosine

Citations are publications that use Tocris products.

Currently there are no citations for N,N-Dimethylsphingosine. Do you know of a great paper that uses N,N-Dimethylsphingosine from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for N,N-Dimethylsphingosine

Protocols

TODO: Add Protocols