N-Methylquipazine dimaleate

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Cat.No. 0566 - N-Methylquipazine dimaleate | C14H17N3.(C4H4O4)2 | CAS No. 171205-17-7
Description: 5-HT3 agonist
Chemical Name: 2-(1-N-Methylpiperazinyl)quinoline dimaleate
Literature (2)

Biological Activity

5-HT3 agonist. Has almost the same affinity for 5-HT3 sites as quipazine but unlike the latter, does not bind to 5-HT1B sites.

Technical Data

M. Wt 459.45
Formula C14H17N3.(C4H4O4)2
Storage Store at RT
CAS Number 171205-17-7
PubChem ID 11957670
Smiles OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CN1CCN(CC1)C1=NC2=C(C=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 50

Preparing Stock Solutions

The following data is based on the product molecular weight 459.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.35 mL 21.77 mL 43.53 mL
2.5 mM 0.87 mL 4.35 mL 8.71 mL
5 mM 0.44 mL 2.18 mL 4.35 mL
25 mM 0.09 mL 0.44 mL 0.87 mL

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References are publications that support the biological activity of the product.

Glennon et al (1989) Binding of arylpiperazines to 5-HT3 serotonin receptors: results of a structure-affinity study. Eur.J.Pharmacol. 168 387 PMID: 2583244

If you know of a relevant reference for N-Methylquipazine dimaleate, please let us know.

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Citations for N-Methylquipazine dimaleate

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Literature in this Area

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Ion Channel

Ion Channel Product Listing

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.