Nα-Methylhistamine dihydrochloride

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Cat.No. 0573 - N-Methylhistamine dihydrochloride | C6H11N3.2HCl | CAS No. 16503-22-3
Description: Non-selective H3 agonist
Chemical Name: N-Methyl-1H-imidazole-4-ethanamine dihydrochloride
Literature (4)

Biological Activity for Nα-Methylhistamine dihydrochloride

Nα-Methylhistamine dihydrochloride is a potent histamine agonist, particularly at H3 receptors (potency relative to histamine is 81, 185, and 270% at H1, H2 and H3 respectively). Also displays agonist properties at H4 receptors to which it binds with moderate affinity (Ki = 23 nM).

Technical Data for Nα-Methylhistamine dihydrochloride

M. Wt 198.09
Formula C6H11N3.2HCl
Storage Desiccate at RT
CAS Number 16503-22-3
PubChem ID 16078977
Smiles Cl.Cl.CNCCC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nα-Methylhistamine dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 19.81 100

Preparing Stock Solutions for Nα-Methylhistamine dihydrochloride

The following data is based on the product molecular weight 198.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.05 mL 25.24 mL 50.48 mL
5 mM 1.01 mL 5.05 mL 10.1 mL
10 mM 0.5 mL 2.52 mL 5.05 mL
50 mM 0.1 mL 0.5 mL 1.01 mL

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Product Datasheets for Nα-Methylhistamine dihydrochloride

References for Nα-Methylhistamine dihydrochloride

References are publications that support the biological activity of the product.

Hill et al (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693

Schwartz et al (1990) A third histamine receptor subtype - characterization, localization and functions of the H3-receptor. Agents Actions 30 13 PMID: 1695431

Zweig et al (1992) Characterization of digitonin-solubilized bovine brain H3 histamine receptor coupled to a guanine nucleotide-binding protein. J.Neurochem. 59 1661 PMID: 1328529

If you know of a relevant reference for Nα-Methylhistamine dihydrochloride, please let us know.

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Keywords: N-Methylhistamine dihydrochloride, N-Methylhistamine dihydrochloride supplier, Non-Selective, H3, agonists, Receptors, Histamine, histaminergic, Nalpha-Methylhistamine, dihydrochloride, 0573, Tocris Bioscience

Citations for Nα-Methylhistamine dihydrochloride

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