Nα-Methylhistamine dihydrochloride

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Cat.No. 0573 - N-Methylhistamine dihydrochloride | C6H11N3.2HCl | CAS No. 16503-22-3
Description: Non-selective H3 agonist
Chemical Name: N-Methyl-1H-imidazole-4-ethanamine dihydrochloride
Datasheet
Citations
Literature

Biological Activity

Potent histamine agonist, particularly at H3 receptors (potency relative to histamine is 81, 185, and 270% at H1, H2 and H3 respectively). Also displays agonist properties at H4 receptors to which it binds with moderate affinity (Ki = 23 nM).

Technical Data

M. Wt 198.09
Formula C6H11N3.2HCl
Storage Desiccate at RT
CAS Number 16503-22-3
PubChem ID 16078977
InChI Key AYUQICXJAMPXPF-UHFFFAOYSA-N
Smiles Cl.Cl.CNCCC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
phosphate buffered saline 19.81 100
water 19.81 100

Preparing Stock Solutions

The following data is based on the product molecular weight 198.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.05 mL 25.24 mL 50.48 mL
5 mM 1.01 mL 5.05 mL 10.1 mL
10 mM 0.5 mL 2.52 mL 5.05 mL
50 mM 0.1 mL 0.5 mL 1.01 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Hill et al (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693

Schwartz et al (1990) A third histamine receptor subtype - characterization, localization and functions of the H3-receptor. Agents Actions 30 13 PMID: 1695431

Zweig et al (1992) Characterization of digitonin-solubilized bovine brain H3 histamine receptor coupled to a guanine nucleotide-binding protein. J.Neurochem. 59 1661 PMID: 1328529


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Citations for Nα-Methylhistamine dihydrochloride

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