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Potent histamine agonist, particularly at H3 receptors (potency relative to histamine is 81, 185, and 270% at H1, H2 and H3 respectively). Also displays agonist properties at H4 receptors to which it binds with moderate affinity (Ki = 23 nM).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 198.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.05 mL||25.24 mL||50.48 mL|
|5 mM||1.01 mL||5.05 mL||10.1 mL|
|10 mM||0.5 mL||2.52 mL||5.05 mL|
|50 mM||0.1 mL||0.5 mL||1.01 mL|
References are publications that support the biological activity of the product.
Hill et al (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693
Schwartz et al (1990) A third histamine receptor subtype - characterization, localization and functions of the H3-receptor. Agents Actions 30 13 PMID: 1695431
Zweig et al (1992) Characterization of digitonin-solubilized bovine brain H3 histamine receptor coupled to a guanine nucleotide-binding protein. J.Neurochem. 59 1661 PMID: 1328529
If you know of a relevant reference for Nα-Methylhistamine dihydrochloride, please let us know.
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Keywords: N-Methylhistamine dihydrochloride, N-Methylhistamine dihydrochloride supplier, Non-Selective, H3, agonists, Receptors, Histamine, histaminergic, Nalpha-Methylhistamine, dihydrochloride, 0573, Tocris Bioscience
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Literature in this Area
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.