Discontinued ProductN-Arachidonyl maleimide (Cat. No. 3329) has been withdrawn from sale for commercial reasons.
Potent, competitive and irreversible monoacylglycerol lipase (MAGL) inhibitor (IC50 = 140 nM). Selectively prevents metabolic inactivation of 2-arachidonoylglycerol (2-AG) by ~ 85% and increases the potency of 2-AG in mouse cerebellum in vitro.
|Storage||Store at -80°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
References are publications that support the biological activity of the product.
Saario et al (2005) Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes. Chem.Biol. 12 649 PMID: 15975510
Blankman et al (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem.Biol. 14 1347 PMID: 18096503
Burston et al (2008) N-arachidonyl maleimide potentiates the pharmalocogical and biochemical effects of the endocannabinoid 2-arachidonylyglycerol through inhibition of monoacylglycerol lipase. J.Pharmacol.Exp.Ther. 327 546 PMID: 18682568
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Keywords: N-Arachidonyl maleimide, N-Arachidonyl maleimide supplier, Potent, competitive, MAGL, inhibitors, inhibits, Monoacylglycerol, Lipases, Esterases, MGL, 3329, Tocris Bioscience
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