N-Arachidonyl maleimide

Discontinued Product

Unfortunately N-Arachidonyl maleimide (Cat. No. 3329) has been withdrawn from sale for commercial reasons.
Cat.No. 3329 - N-Arachidonyl maleimide | C24H35NO2 | CAS No. 876305-42-9
Description: Potent, competitive MAGL inhibitor
Chemical Name: 1-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yl-1H-pyrrole-2,5-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent, competitive and irreversible monoacylglycerol lipase (MAGL) inhibitor (IC50 = 140 nM). Selectively prevents metabolic inactivation of 2-arachidonoylglycerol (2-AG) by ~ 85% and increases the potency of 2-AG in mouse cerebellum in vitro.

Technical Data

M. Wt 369.54
Formula C24H35NO2
Storage Store at -80°C
Purity ≥98% (HPLC)
CAS Number 876305-42-9
Smiles O=C1C=CC(N1CCCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Saario et al (2005) Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes. Chem.Biol. 12 649 PMID: 15975510

Blankman et al (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem.Biol. 14 1347 PMID: 18096503

Burston et al (2008) N-arachidonyl maleimide potentiates the pharmalocogical and biochemical effects of the endocannabinoid 2-arachidonylyglycerol through inhibition of monoacylglycerol lipase. J.Pharmacol.Exp.Ther. 327 546 PMID: 18682568

View Related Products by Target

View Related Products by Product Action

View all Lipase Inhibitors

Keywords: N-Arachidonyl maleimide, supplier, Potent, competitive, MAGL, inhibitors, inhibits, Monoacylglycerol, Lipases, Esterases, MGL, Lipases, Lipases, Tocris Bioscience

Citations for N-Arachidonyl maleimide

Citations are publications that use Tocris products.

Currently there are no citations for N-Arachidonyl maleimide.

Reviews for N-Arachidonyl maleimide

There are currently no reviews for this product. Be the first to review N-Arachidonyl maleimide and earn rewards!

Have you used N-Arachidonyl maleimide?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cannabinoid Receptor Ligands

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.