N-Arachidonyl maleimide

Discontinued Product

N-Arachidonyl maleimide (Cat. No. 3329) has been withdrawn from sale for commercial reasons.
Description: Potent, competitive MAGL inhibitor
Chemical Name: 1-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yl-1H-pyrrole-2,5-dione
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for N-Arachidonyl maleimide

Potent, competitive and irreversible monoacylglycerol lipase (MAGL) inhibitor (IC50 = 140 nM). Selectively prevents metabolic inactivation of 2-arachidonoylglycerol (2-AG) by ~ 85% and increases the potency of 2-AG in mouse cerebellum in vitro.

Technical Data for N-Arachidonyl maleimide

M. Wt 369.54
Formula C24H35NO2
Storage Store at -80°C
Purity ≥98% (HPLC)
CAS Number 876305-42-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for N-Arachidonyl maleimide

Certificate of Analysis / Product Datasheet
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References for N-Arachidonyl maleimide

References are publications that support the biological activity of the product.

Saario et al (2005) Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes. Chem.Biol. 12 649 PMID: 15975510

Blankman et al (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem.Biol. 14 1347 PMID: 18096503

Burston et al (2008) N-arachidonyl maleimide potentiates the pharmalocogical and biochemical effects of the endocannabinoid 2-arachidonylyglycerol through inhibition of monoacylglycerol lipase. J.Pharmacol.Exp.Ther. 327 546 PMID: 18682568

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Keywords: N-Arachidonyl maleimide, N-Arachidonyl maleimide supplier, Potent, competitive, MAGL, inhibitors, inhibits, Monoacylglycerol, Lipases, Esterases, MGL, 3329, Tocris Bioscience

Citations for N-Arachidonyl maleimide

Citations are publications that use Tocris products.

Currently there are no citations for N-Arachidonyl maleimide.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.