N-Arachidonyl maleimide

Discontinued Product

N-Arachidonyl maleimide (Cat. No. 3329) has been withdrawn from sale for commercial reasons.
Cat.No. 3329 - N-Arachidonyl maleimide | C24H35NO2 | CAS No. 876305-42-9
Description: Potent, competitive MAGL inhibitor
Chemical Name: 1-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yl-1H-pyrrole-2,5-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent, competitive and irreversible monoacylglycerol lipase (MAGL) inhibitor (IC50 = 140 nM). Selectively prevents metabolic inactivation of 2-arachidonoylglycerol (2-AG) by ~ 85% and increases the potency of 2-AG in mouse cerebellum in vitro.

Technical Data

M. Wt 369.54
Formula C24H35NO2
Storage Store at -80°C
Purity ≥98% (HPLC)
CAS Number 876305-42-9
Smiles O=C1C=CC(N1CCCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Saario et al (2005) Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes. Chem.Biol. 12 649 PMID: 15975510

Blankman et al (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem.Biol. 14 1347 PMID: 18096503

Burston et al (2008) N-arachidonyl maleimide potentiates the pharmalocogical and biochemical effects of the endocannabinoid 2-arachidonylyglycerol through inhibition of monoacylglycerol lipase. J.Pharmacol.Exp.Ther. 327 546 PMID: 18682568

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Keywords: N-Arachidonyl maleimide, N-Arachidonyl maleimide supplier, Potent, competitive, MAGL, inhibitors, inhibits, Monoacylglycerol, Lipases, Esterases, MGL, 3329, Tocris Bioscience

Citations for N-Arachidonyl maleimide

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