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A partial agonist for melatonin receptors in the retina. Also used for determination of serotonin N-acetyl transferase.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 202.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.94 mL||24.72 mL||49.44 mL|
|5 mM||0.99 mL||4.94 mL||9.89 mL|
|10 mM||0.49 mL||2.47 mL||4.94 mL|
|50 mM||0.1 mL||0.49 mL||0.99 mL|
References are publications that support the biological activity of the product.
Dubocovich (1985) Characterization of a retinal melatonin receptor. J.Pharmacol.Exp.Ther. 234 395 PMID: 2991499
Dubocovich (1988) Luzindole (NO 774): a novel melatonin receptor antagonist. J.Pharmacol.Exp.Ther. 246 902 PMID: 2843633
Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083
Thomas et al (1990) Arylalkylamine (serotonin) N-acetyl transferase assay using high-performance liquid-chromatography with fluorescence or electrochemical detection of N-acetyltryptamine. Anal.Biochem. 184 228 PMID: 2327568
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Keywords: N-Acetyltryptamine, N-Acetyltryptamine supplier, Melatonin, partial, agonists, MT1, MT2, MT3, antagonists, Serotonin, N-acetyltransferase, Substrate, serotonin, N-acetyl, transferase, MT, Receptors, 5-HT3, 5-Hydroxytryptamine, 5-HT, Transferases, activators, (MT), 5-HT-Related, Enzyme, Substrates, /, Activators, Other, 0357, Tocris Bioscience
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