N-Acetylpuromycin

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Cat.No. 5679 - N-Acetylpuromycin | C24H31N7O6 | CAS No. 22852-13-7
Description: Downregulates SnoN and Ski protein expression; promotes TGF-β signaling
Chemical Name: 3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Downregulates SnoN and Ski protein expression; promotes TGF-β signaling, independently of MAPK activation. Does not bind ribosomes or block protein synthesis.

Technical Data

M. Wt 513.55
Formula C24H31N7O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 22852-13-7
PubChem ID 46173769
InChI Key LADKVYSQIGJMFP-IYRMOJGWSA-N
Smiles O[C@@H]1[C@H](NC([C@@H](NC(C)=O)CC4=CC=C(OC)C=C4)=O)[C@@H](CO)O[C@H]1N3C2=NC=NC(N(C)C)=C2N=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.35 100
1eq. HCl 51.35 100

Preparing Stock Solutions

The following data is based on the product molecular weight 513.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.74 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL
10 mM 0.19 mL 0.97 mL 1.95 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hernández-Damián et al (2013) Downregulation of SnoN oncoprotein induced by antibiotics anisomycin and puromycin positively regulates transforming growth factor-β signals. Biochim.Biophys.Acta. 1830 5049 PMID: 23872350


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Keywords: N-Acetylpuromycin, N-Acetylpuromycin supplier, SnoN, SKI, proteins, downregulates, downregulation, transforming, growth, factor, beta, TGF-beta, TGF-B, TGF-β, signaling, ribosomes, Receptors, 5679, Tocris Bioscience

Citations for N-Acetylpuromycin

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
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  • Angiogenesis
  • Invasion and Metastasis
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  • Complement System
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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
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  • MAPK Signaling
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Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cells

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for N-Acetylpuromycin

TGF-β

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.