Pricing Availability Delivery Time Qty
Cat.No. 5679 - N-Acetylpuromycin | C24H31N7O6 | CAS No. 22852-13-7
Description: Downregulates SnoN and Ski protein expression; promotes TGF-β signaling
Chemical Name: 3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine
Purity: ≥98% (HPLC)

Biological Activity

Downregulates SnoN and Ski protein expression; promotes TGF-β signaling, independently of MAPK activation. Does not bind ribosomes or block protein synthesis.

Technical Data

M. Wt 513.55
Formula C24H31N7O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 22852-13-7
PubChem ID 46173769
Smiles O[C@@H]1[C@H](NC([C@@H](NC(C)=O)CC4=CC=C(OC)C=C4)=O)[C@@H](CO)O[C@H]1N3C2=NC=NC(N(C)C)=C2N=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 51.35 100
DMSO 51.35 100

Preparing Stock Solutions

The following data is based on the product molecular weight 513.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.74 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL
10 mM 0.19 mL 0.97 mL 1.95 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Hernández-Damián et al (2013) Downregulation of SnoN oncoprotein induced by antibiotics anisomycin and puromycin positively regulates transforming growth factor-β signals. Biochim.Biophys.Acta. 1830 5049 PMID: 23872350

If you know of a relevant reference for N-Acetylpuromycin, please let us know.

Keywords: N-Acetylpuromycin, supplier, SnoN, SKI, proteins, downregulates, downregulation, transforming, growth, factor, beta, TGF-beta, TGF-B, TGF-β, signaling, ribosomes, TGF-beta, Receptors, TGF-beta, Receptors, Tocris Bioscience

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