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Biological Activity for N-Acetylpuromycin
N-Acetylpuromycin downregulates SnoN and Ski protein expression; promotes TGF-β signaling, independently of MAPK activation. Does not bind ribosomes or block protein synthesis.
Technical Data for N-Acetylpuromycin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for N-Acetylpuromycin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for N-Acetylpuromycin
The following data is based on the product molecular weight 513.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.95 mL||9.74 mL||19.47 mL|
|5 mM||0.39 mL||1.95 mL||3.89 mL|
|10 mM||0.19 mL||0.97 mL||1.95 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
Product Datasheets for N-Acetylpuromycin
References for N-Acetylpuromycin
References are publications that support the biological activity of the product.
Hernández-Damián et al (2013) Downregulation of SnoN oncoprotein induced by antibiotics anisomycin and puromycin positively regulates transforming growth factor-β signals. Biochim.Biophys.Acta. 1830 5049 PMID: 23872350
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Keywords: N-Acetylpuromycin, N-Acetylpuromycin supplier, SnoN, SKI, proteins, downregulates, downregulation, transforming, growth, factor, beta, TGF-beta, TGF-B, TGF-β, signaling, ribosomes, Receptors, 5679, Tocris Bioscience
2 Citations for N-Acetylpuromycin
Citations are publications that use Tocris products. Selected citations for N-Acetylpuromycin include:
Alun R et al (2020) A Semiautomated, Phenotypic, In Vitro Scratch Assay for Assessing Retinal Pigment Epithelial Cell Wound Healing. J Ocul Pharmacol Ther 36 257-266 PMID: 32027217
Hossein et al (2020) Directed differentiation of regulatory T cells from naive T cells and prevention of their inflammation-mediated instability using small molecules. Clin Exp Immunol 201 205-221 PMID: 32403163
Do you know of a great paper that uses N-Acetylpuromycin from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.