N-Acetylpuromycin

Pricing Availability Delivery Time Qty
Cat.No. 5679 - N-Acetylpuromycin | C24H31N7O6 | CAS No. 22852-13-7
Description: Downregulates SnoN and Ski protein expression; promotes TGF-β signaling
Chemical Name: 3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Downregulates SnoN and Ski protein expression; promotes TGF-β signaling, independently of MAPK activation. Does not bind ribosomes or block protein synthesis.

Technical Data

M. Wt 513.55
Formula C24H31N7O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 22852-13-7
PubChem ID 46173769
InChI Key LADKVYSQIGJMFP-IYRMOJGWSA-N
Smiles O[C@@H]1[C@H](NC([C@@H](NC(C)=O)CC4=CC=C(OC)C=C4)=O)[C@@H](CO)O[C@H]1N3C2=NC=NC(N(C)C)=C2N=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 51.35 100
DMSO 51.35 100

Preparing Stock Solutions

The following data is based on the product molecular weight 513.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.74 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL
10 mM 0.19 mL 0.97 mL 1.95 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hernández-Damián et al (2013) Downregulation of SnoN oncoprotein induced by antibiotics anisomycin and puromycin positively regulates transforming growth factor-β signals. Biochim.Biophys.Acta. 1830 5049 PMID: 23872350


If you know of a relevant reference for N-Acetylpuromycin, please let us know.

Keywords: SnoN SKI proteins downregulates downregulation transforming growth factor beta TGF-beta TGF-B TGF-β signaling ribosomes TGF-beta Receptors

Citations for N-Acetylpuromycin

Citations are publications that use Tocris products.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for N-Acetylpuromycin

TGF-β

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.

Protocols

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