N-Acetylcysteine amide

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Cat.No. 5619 - N-Acetylcysteine amide | C5H10N2O2S | CAS No. 38520-57-9
Description: Glutathione (GSH) precursor; neuroprotective
Chemical Name: (2R)-2-(Acetylamino)-3-mercaptopropanamide
Datasheet
Citations (1)
Literature

Biological Activity

Glutathione (GSH) precursor and cell permeable antioxidant. Improves neuronal mitochondrial bioenergetics, reduces tissue damage and enhances functional recovery following spinal cord injury in rats. Also enhances behavioral recovery in rats following traumatic brain injury. Neuroprotective.

Technical Data

M. Wt 162.21
Formula C5H10N2O2S
Storage Store at -20°C
CAS Number 38520-57-9
PubChem ID 10176265
InChI Key UJCHIZDEQZMODR-BYPYZUCNSA-N
Smiles SC[C@H](NC(C)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.22 100
water 16.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 162.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.16 mL 30.82 mL 61.65 mL
5 mM 1.23 mL 6.16 mL 12.33 mL
10 mM 0.62 mL 3.08 mL 6.16 mL
50 mM 0.12 mL 0.62 mL 1.23 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Patel et al (2014) N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma. Exp.Neurol. 257 95 PMID: 24805071

Pandya et al (2014) N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Exp.Neurol. 257 106 PMID: 24792639


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Keywords: N-Acetylcysteine amide, supplier, cell, permeable, antioxidant, neuroprotective, glutathione, precursor, GSH, organoids, Antioxidants, Antioxidants, Tocris Bioscience

1 Citation for N-Acetylcysteine amide

Citations are publications that use Tocris products. Selected citations for N-Acetylcysteine amide include:

Gutierrez et al (2014) The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity. J Biol Chem 289 33568 PMID: 25301941


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