N-Acetylcysteine amide

Pricing Availability   Qty
Cat.No. 5619 - N-Acetylcysteine amide | C5H10N2O2S | CAS No. 38520-57-9
Description: Glutathione (GSH) precursor; neuroprotective
Chemical Name: (2R)-2-(Acetylamino)-3-mercaptopropanamide
Citations (1)
Reviews (1)
Protocols (1)

Biological Activity for N-Acetylcysteine amide

N-Acetylcysteine amide is a glutathione (GSH) precursor and cell permeable antioxidant. Improves neuronal mitochondrial bioenergetics, reduces tissue damage and enhances functional recovery following spinal cord injury in rats. Also enhances behavioral recovery in rats following traumatic brain injury. Neuroprotective.

Technical Data for N-Acetylcysteine amide

M. Wt 162.21
Formula C5H10N2O2S
Storage Store at -20°C
CAS Number 38520-57-9
PubChem ID 10176265
Smiles SC[C@H](NC(C)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for N-Acetylcysteine amide

Solvent Max Conc. mg/mL Max Conc. mM
water 16.22 100
DMSO 16.22 100

Preparing Stock Solutions for N-Acetylcysteine amide

The following data is based on the product molecular weight 162.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.16 mL 30.82 mL 61.65 mL
5 mM 1.23 mL 6.16 mL 12.33 mL
10 mM 0.62 mL 3.08 mL 6.16 mL
50 mM 0.12 mL 0.62 mL 1.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for N-Acetylcysteine amide

Certificate of Analysis / Product Datasheet
Select another batch:

References for N-Acetylcysteine amide

References are publications that support the biological activity of the product.

Patel et al (2014) N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma. Exp.Neurol. 257 95 PMID: 24805071

Pandya et al (2014) N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Exp.Neurol. 257 106 PMID: 24792639

If you know of a relevant reference for N-Acetylcysteine amide, please let us know.

View Related Products by Target

Keywords: N-Acetylcysteine amide, N-Acetylcysteine amide supplier, cell, permeable, antioxidant, neuroprotective, glutathione, precursor, GSH, organoids, Antioxidants, 5619, Tocris Bioscience

1 Citation for N-Acetylcysteine amide

Citations are publications that use Tocris products. Selected citations for N-Acetylcysteine amide include:

Gutierrez et al (2014) The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity. J Biol Chem 289 33568 PMID: 25301941

Do you know of a great paper that uses N-Acetylcysteine amide from Tocris? Please let us know.

Reviews for N-Acetylcysteine amide

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used N-Acetylcysteine amide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

NAC inhibits HOCl-LDL-induced CaMKII oxidation.
By Chintan Koyani on 10/22/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Cardiomyocytes

HL-1 cardiomyocytes were pre-treated with Pyrrolidinedithiocarbamate (PDTC, 1 mM), Tempol (1 mM) or N-Acetylcysteine (NAC, 1 mM) for 30 min and stimulated with HOCl-LDL (200 µg/ml) for 2 h to follow CaMKII oxidation using Western blot.

review image

Protocols for N-Acetylcysteine amide

The following protocol features additional information for the use of N-Acetylcysteine amide (Cat. No. 5619).