N-(3-Oxododecanoyl)-L-homoserine lactone

Discontinued Product

N-(3-Oxododecanoyl)-L-homoserine lactone (Cat. No. 6548) has been withdrawn from sale for commercial reasons.
Description: Bacterial quorum sensing autoinducer; immunomodulator
Chemical Name: 3-Oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]dodecanamide

Biological Activity

N-(3-Oxododecanoyl)-L-homoserine lactone is a bacterial quorum sensing signal molecule. Inhibits lymphocyte proliferation and TNF-α and IL-12 production by LPS-stimulated macrophages. Inhibits or promotes antibody production at high and low concentrations, respectively, in keyhole limpet hemocyanin (KLH)-stimulated spleen cells. Immunomodulator.

Technical Data

M. Wt 297.39
Formula C16H27NO4
Storage Store at -20°C
CAS Number 168982-69-2
PubChem ID 3246941

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.


References are publications that support the biological activity of the product.

Telford et al (1998) The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity. Infect.Immun. 66 36 PMID: 9423836

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Keywords: N-(3-Oxododecanoyl)-L-homoserine lactone, N-(3-Oxododecanoyl)-L-homoserine lactone supplier, OdDHL, quorum, sensing, sensors, autoinducers, Gram-negative, bacterial, Pseudomonas, aeruginosa, signaling, signalling, immunomodulator, Immunosuppressants, 6548, Tocris Bioscience

Citations for N-(3-Oxododecanoyl)-L-homoserine lactone

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