N-(3-Oxododecanoyl)-L-homoserine lactone

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Cat.No. 6548 - N-(3-Oxododecanoyl)-L-homoserine lactone | C16H27NO4 | CAS No. 168982-69-2
Description: Bacterial quorum sensing autoinducer; immunomodulator
Chemical Name: 3-Oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]dodecanamide
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Biological Activity

Bacterial quorum sensing signal molecule. Inhibits lymphocyte proliferation and TNF-α and IL-12 production by LPS-stimulated macrophages. Inhibits or promotes antibody production at high and low concentrations, respectively, in keyhole limpet hemocyanin (KLH)-stimulated spleen cells. Immunomodulator.

Technical Data

M. Wt 297.39
Formula C16H27NO4
Storage Store at -20°C
CAS Number 168982-69-2
PubChem ID 3246941
InChI Key PHSRRHGYXQCRPU-AWEZNQCLSA-N
Smiles CCCCCCCCCC(CC(N[C@H]1CCOC1=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 297.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.81 mL 33.63 mL
5 mM 0.67 mL 3.36 mL 6.73 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Telford et al (1998) The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity. Infect.Immun. 66 36 PMID: 9423836


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Keywords: N-(3-Oxododecanoyl)-L-homoserine lactone, N-(3-Oxododecanoyl)-L-homoserine lactone supplier, OdDHL, quorum, sensing, sensors, autoinducers, Gram-negative, bacterial, Pseudomonas, aeruginosa, signaling, signalling, immunomodulator, Immunosuppressants, 6548, Tocris Bioscience

Citations for N-(3-Oxododecanoyl)-L-homoserine lactone

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