Myricetin

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Cat.No. 6189 - Myricetin | C15H10O8 | CAS No. 529-44-2
Description: Irreversible TrxR inhibitor
Chemical Name: 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Irreversible TrxR inhibitor (IC50 = 0.62 μM). Exhibits concentration-, time- and NADH-dependent TrxR inhibition. Results in the oxidation of Trx and reduced TrxR activity in vitro in addition to the accumulation of cells in sub-G1 phase. Reduces neoplastic transformation and induces cell death in cancer cell lines. Chemotherapeutic.

Technical Data

M. Wt 318.24
Formula C15H10O8
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 529-44-2
PubChem ID 5281672
InChI Key IKMDFBPHZNJCSN-UHFFFAOYSA-N
Smiles OC1=CC(O)=C2C(OC(C3=CC(O)=C(C(O)=C3)O)=C(C2=O)O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.82 100
ethanol 15.91 50

Preparing Stock Solutions

The following data is based on the product molecular weight 318.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.14 mL 15.71 mL 31.42 mL
5 mM 0.63 mL 3.14 mL 6.28 mL
10 mM 0.31 mL 1.57 mL 3.14 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lu et al (2006) Inhibition of mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer.Res. 66 4410 PMID: 16618767

Lu & Holmgren et al (2009) Selenoproteins. J.Biol.Chem. 284 723 PMID: 8757362

Ko et al (2005) Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade. Biochem.Pharmacol. 69 913 PMID: 15748703

Devi et al (2015) Molecular mechanisms underlying anticancer effects of myricetin. Life.Sci. 142 19 PMID: 26455550

Ong & Khoo et al (1997) Biological effects of myricetin. Gen.Pharmacol. 29 121 PMID: 9251891


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Keywords: Myricetin, supplier, Myricetin, TrxR, Thioredoxin, reductase, irreversible, inhibitors, inhibits, chemotherapeutic, cancer, cell, death, TrxR, TrxR, Tocris Bioscience

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