Irreversible TrxR inhibitor (IC50 = 0.62 μM). Exhibits concentration-, time- and NADH-dependent TrxR inhibition. Results in the oxidation of Trx and reduced TrxR activity in vitro in addition to the accumulation of cells in sub-G1 phase. Reduces neoplastic transformation and induces cell death in cancer cell lines. Chemotherapeutic.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 318.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.14 mL||15.71 mL||31.42 mL|
|5 mM||0.63 mL||3.14 mL||6.28 mL|
|10 mM||0.31 mL||1.57 mL||3.14 mL|
|50 mM||0.06 mL||0.31 mL||0.63 mL|
References are publications that support the products' biological activity.
Lu et al (2006) Inhibition of mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer.Res. 66 4410 PMID: 16618767
Lu & Holmgren et al (2009) Selenoproteins. J.Biol.Chem. 284 723 PMID: 18757362
Ko et al (2005) Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade. Biochem.Pharmacol. 69 913 PMID: 15748703
Devi et al (2015) Molecular mechanisms underlying anticancer effects of myricetin. Life.Sci. 142 19 PMID: 26455550
Ong & Khoo et al (1997) Biological effects of myricetin. Gen.Pharmacol. 29 121 PMID: 9251891
If you know of a relevant reference for Myricetin, please let us know.
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Keywords: Myricetin, supplier, Myricetin, TrxR, Thioredoxin, reductase, irreversible, inhibitors, inhibits, chemotherapeutic, cancer, cell, death, TrxR, TrxR, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.