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Cat.No. 0432 - MY-5445 | C20H14ClN3 | CAS No. 78351-75-4
Description: PDE5 inhibitor
Chemical Name: 1-(3-Chlorophenylamino)-4-phenylphthalazine
Reviews (1)

Biological Activity

Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC50 = 0.5 μM).

Compound Libraries

MY-5445 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 331.8
Formula C20H14ClN3
Storage Store at RT
CAS Number 78351-75-4
PubChem ID 1348
Smiles ClC1=CC(NC2=C3C=CC=CC3=C(N=N2)C2=CC=CC=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 50 mM in DMSO and to 5 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 331.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.14 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Hagiwara et al (1984) Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation. J.Pharmacol.Exp.Ther. 228 467 PMID: 6141286

Hidaka and Endo et al (1984) Selective inhibitors of three forms of cyclic nucleotide phosphodiesterase, basic and potential clinical applications. Adv.Cyclic Nucleotide Protein Phosphorylation Res. 16 245 PMID: 6144253

If you know of a relevant reference for MY-5445, please let us know.

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Keywords: MY-5445, supplier, PDE5, inhibitors, inhibits, PDE, Phosphodiesterases, MY, 5445, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

Citations for MY-5445

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Reviews for MY-5445

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By Abhijit Nirwane on 01/08/2018
Assay Type: In Vivo
Species: Other

In vivo reproductive studies

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