Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC50 = 0.5 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 50 mM in DMSO and to 5 mM in ethanol|
Preparing Stock Solutions
The following data is based on the product molecular weight 331.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.01 mL||15.07 mL||30.14 mL|
|5 mM||0.6 mL||3.01 mL||6.03 mL|
|10 mM||0.3 mL||1.51 mL||3.01 mL|
|50 mM||0.06 mL||0.3 mL||0.6 mL|
References are publications that support the products' biological activity.
Hagiwara et al (1984) Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation. J.Pharmacol.Exp.Ther. 228 467 PMID: 6141286
Hidaka and Endo et al (1984) Selective inhibitors of three forms of cyclic nucleotide phosphodiesterase, basic and potential clinical applications. Adv.Cyclic Nucleotide Protein Phosphorylation Res. 16 245 PMID: 6144253
If you know of a relevant reference for MY-5445, please let us know.
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Keywords: MY-5445, supplier, PDE5, inhibitors, inhibits, PDE, Phosphodiesterases, MY, 5445, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience
Citations for MY-5445
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