MY-5445

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Cat.No. 0432 - MY-5445 | C20H14ClN3 | CAS No. 78351-75-4
Description: PDE5 inhibitor
Chemical Name: 1-(3-Chlorophenylamino)-4-phenylphthalazine
Datasheet
Citations
Literature

Biological Activity

Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC50 = 0.5 μM).

Compound Libraries

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Technical Data

M. Wt 331.8
Formula C20H14ClN3
Storage Store at RT
CAS Number 78351-75-4
PubChem ID 1348
InChI Key CEHQLKSLMFIHBF-UHFFFAOYSA-N
Smiles ClC1=CC(NC2=C3C=CC=CC3=C(N=N2)C2=CC=CC=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 50 mM in DMSO and to 5 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 331.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.14 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hagiwara et al (1984) Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation. J.Pharmacol.Exp.Ther. 228 467 PMID: 6141286

Hidaka and Endo et al (1984) Selective inhibitors of three forms of cyclic nucleotide phosphodiesterase, basic and potential clinical applications. Adv.Cyclic Nucleotide Protein Phosphorylation Res. 16 245 PMID: 6144253


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Keywords: PDE5 inhibitors inhibits PDE Phosphodiesterases MY 5445 Phosphodiesterases

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Cardiovascular

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