Muristerone A

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Cat.No. 3816 - Muristerone A | C27H44O8 | CAS No. 38778-30-2
Description: Stimulates Bcl-XL mRNA transcription; antiapoptotic
Chemical Name: (2β,3β,5β,11α,22R)-2,3,5,11,14,20,22-Heptahydroxycholest-7-en-6-one
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.

Technical Data

M. Wt 496.63
Formula C27H44O8
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 38778-30-2
PubChem ID 122217
InChI Key LRJUYAVTHIEHAI-LHBNDURVSA-N
Smiles O[C@@H]1[C@H](O)C[C@](C(C=C3[C@@]([H])2[C@H](O)C[C@@]4(C)[C@](O)3CC[C@@]([H])4[C@](O)(C)[C@H](O)CCC(C)C)=O)(O)[C@]2(C)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 496.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.07 mL 20.14 mL
5 mM 0.4 mL 2.01 mL 4.03 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Patrick et al (2001) Muristerone A-induced nerve growth factor release from genetically engineered human dermal fibroblasts for peripheral nerve tissue engineering. Tissue Eng. 7 303 PMID: 11429150

No et al (1996) Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc.Natl.Acad.Sci.USA 93 3346 PMID:

Bosser and Zornig (2005) Agonists of an ecdysone-inducible mammalian expression system inhibit Fas-ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. Cell Death Diff. 13 189 PMID:


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Keywords: ecdysone analogs analogues inhibits antiapoptotic Bcl-XL inducing agents MuristeroneA Bcl-2 Family

Citations for Muristerone A

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Literature in this Area

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Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Muristerone A

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

Protocols

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