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MSA 2 is a non-nucleotide STING agonist (EC50 values are 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively). Exhibits antitumor activity and stimulates interferon-β secretion in tumors. Induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models. Orally bioavailable.
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|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 294.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.4 mL||16.99 mL||33.98 mL|
|5 mM||0.68 mL||3.4 mL||6.8 mL|
|10 mM||0.34 mL||1.7 mL||3.4 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
References are publications that support the biological activity of the product.
Pan et al (2020) An orally available non-nucleotide STING agonist with antitumor activity. Science 369 eaba6098 PMID: 32820094
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Keywords: MSA 2, MSA 2 supplier, MSA2, STING, agonists, agonism, orally, bioavailable, STING-Dependent, Signaling, 7353, Tocris Bioscience
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