Pricing Availability   Qty
Description: Non-nucleotide STING agonist; orally bioavailable
Chemical Name: 4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for MSA 2

MSA 2 is a non-nucleotide STING agonist (EC50 values are 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively). Exhibits antitumor activity and stimulates interferon-β secretion in tumors. Induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models. Orally bioavailable.

Compound Libraries for MSA 2

MSA 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MSA 2

M. Wt 294.32
Formula C14H14O5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 129425-81-6
PubChem ID 23035251
Smiles COC1=CC2=C(C=C1OC)C=C(C(CCC(O)=O)=O)S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MSA 2

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.43 100

Preparing Stock Solutions for MSA 2

The following data is based on the product molecular weight 294.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.4 mL 16.99 mL 33.98 mL
5 mM 0.68 mL 3.4 mL 6.8 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References for MSA 2

References are publications that support the biological activity of the product.

Pan et al (2020) An orally available non-nucleotide STING agonist with antitumor activity. Science 369 eaba6098 PMID: 32820094

If you know of a relevant reference for MSA 2, please let us know.

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Keywords: MSA 2, MSA 2 supplier, MSA2, STING, agonists, agonism, orally, bioavailable, STING-Dependent, Signaling, 7353, Tocris Bioscience

Citations for MSA 2

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Literature in this Area

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