Home / Pharmacology / GPCRs / 7-TM Receptors / Adenosine Receptors / Adenosine A3 Receptors / Adenosine A3 Receptor Agonists / MRS 5698

MRS 5698

Cat. No. 5428 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 5428 - MRS 5698 | C28H23ClF2N6O3 | CAS No. 1377273-00-1
Description: High affinity and selective A3 agonist
Chemical Name: (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Purity: ≥96% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MRS 5698

MRS 5698 is a high affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM); displays >1000-fold selectivity over A1 and A2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable.

Technical Data for MRS 5698

M. Wt 564.97
Formula C28H23ClF2N6O3
Storage Store at -20°C
Purity ≥96% (HPLC)
CAS Number 1377273-00-1
PubChem ID 57523213
InChI Key LYLLLJJYBWLGHW-CIZVZKTGSA-N
Smiles O=[C@](NC)[C@@]1(C2)[C@H]2[C@@H](N3C(N=C(C#CC6=CC(F)=C(F)C=C6)N=C4NCC5=CC(Cl)=CC=C5)=C4N=C3)[C@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MRS 5698

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.65 10

Preparing Stock Solutions for MRS 5698

The following data is based on the product molecular weight 564.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.7 mL 88.5 mL 177 mL
0.5 mM 3.54 mL 17.7 mL 35.4 mL
1 mM 1.77 mL 8.85 mL 17.7 mL
5 mM 0.35 mL 1.77 mL 3.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for MRS 5698

References are publications that support the biological activity of the product.

Little et al (2015) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain 138 28 PMID: 25414036

Tosh et al (2012) Structure-guided design of A3 adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. J.Med.Chem. 55 4847 PMID: 22559880

Tosh et al (2015) Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 11 371 PMID: 26111639

If you know of a relevant reference for MRS 5698, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Adenosine A3 Receptor Agonists

Keywords: MRS 5698, MRS 5698 supplier, High, affinity, selective, A3, adenosine, receptors, agonists, antinociceptive, MRS5698, Adenosine, Receptors, 5428, Tocris Bioscience

1 Citation for MRS 5698

Citations are publications that use Tocris products. Selected citations for MRS 5698 include:

Fong et al (2019) Antitumor effects of MRS5698, a cordycepin derivative, on endometrial cancer cells Natural Product Communications 14 1

Do you know of a great paper that uses MRS 5698 from Tocris? Please let us know.

Reviews for MRS 5698

There are currently no reviews for this product. Be the first to review MRS 5698 and earn rewards!

Have you used MRS 5698?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.