MRS 5698

Discontinued Product

MRS 5698 (Cat. No. 5428) has been withdrawn from sale for commercial reasons.
Description: High affinity and selective A3 agonist
Chemical Name: (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Purity: ≥95% (HPLC)
Citations (2)

Biological Activity for MRS 5698

MRS 5698 is a high affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM); displays >1000-fold selectivity over A1 and A2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable.

Technical Data for MRS 5698

M. Wt 564.97
Formula C28H23ClF2N6O3
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1377273-00-1
PubChem ID 57523213
Smiles O=[C@](NC)[C@@]1(C2)[C@H]2[C@@H](N3C(N=C(C#CC6=CC(F)=C(F)C=C6)N=C4NCC5=CC(Cl)=CC=C5)=C4N=C3)[C@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: MRS 5698, MRS 5698 supplier, High, affinity, selective, A3, adenosine, receptors, agonists, antinociceptive, MRS5698, Adenosine, Receptors, 5428, Tocris Bioscience

2 Citations for MRS 5698

Citations are publications that use Tocris products. Selected citations for MRS 5698 include:

Lei et al (2018) Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration. J Mol Med (Berl) 96 1049-1060 PMID: 30088034

Fong et al (2019) Antitumor effects of MRS5698, a cordycepin derivative, on endometrial cancer cells Natural Product Communications 14 1

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