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Biological Activity for MRS 5698
MRS 5698 is a high affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM); displays >1000-fold selectivity over A1 and A2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable.
Technical Data for MRS 5698
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MRS 5698
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for MRS 5698
The following data is based on the product molecular weight 564.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||17.7 mL||88.5 mL||177 mL|
|0.5 mM||3.54 mL||17.7 mL||35.4 mL|
|1 mM||1.77 mL||8.85 mL||17.7 mL|
|5 mM||0.35 mL||1.77 mL||3.54 mL|
References for MRS 5698
References are publications that support the biological activity of the product.
Little et al (2015) Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain 138 28 PMID: 25414036
Tosh et al (2012) Structure-guided design of A3 adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. J.Med.Chem. 55 4847 PMID: 22559880
Tosh et al (2015) Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 11 371 PMID: 26111639
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1 Citation for MRS 5698
Citations are publications that use Tocris products. Selected citations for MRS 5698 include:
Fong et al (2019) Antitumor effects of MRS5698, a cordycepin derivative, on endometrial cancer cells Natural Product Communications 14 1
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Literature in this Area
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