MRS 3777 hemioxalate

Pricing Availability Delivery Time Qty
Cat.No. 2403 - MRS 3777 hemioxalate | C17H19N5O.½C2H2O4 | CAS No. 1186195-57-2
Description: High affinity, selective A3 antagonist
Chemical Name: 2-Phenoxy-6-(cyclohexylamino)purine hemioxalate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

High affinity adenosine A3 receptor antagonist (Ki = 47 nM) that displays > 200-fold selectivity versus A1, A2A and A2B receptors.

Compound Libraries

MRS 3777 hemioxalate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 354.39
Formula C17H19N5O.½C2H2O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1186195-57-2
PubChem ID 56972200
InChI Key ICOKMZZMQHZKGX-UHFFFAOYSA-N
Smiles OC(=O)C(O)=O.C1CCC(CC1)NC1=C2N=CNC2=NC(OC2=CC=CC=C2)=N1.C1CCC(CC1)NC1=C2N=CNC2=NC(OC2=CC=CC=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.72 50

Preparing Stock Solutions

The following data is based on the product molecular weight 354.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.22 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Perreira et al (2005) "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J.Med.Chem. 48 4910 PMID: 16033270

Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247 PMID: 16518376

Moro et al (2006) Progress in the pursuit of therapeutic adenosine receptor antagonists. Med.Res.Rev. 26 131 PMID: 16380972


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Keywords: MRS 3777 hemioxalate, supplier, High, affinity, selective, A3, antagonists, Receptors, adenosines, MRS3777, hemioxalate, Adenosine, A3, Receptors, Adenosine, A3, Receptors, Tocris Bioscience

1 Citation for MRS 3777 hemioxalate

Citations are publications that use Tocris products. Selected citations for MRS 3777 hemioxalate include:

Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Nature 14 201 PMID: 26597723


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