MRS 3777 hemioxalate

Pricing Availability   Qty
Cat.No. 2403 - MRS 3777 hemioxalate | C17H19N5O.½C2H2O4 | CAS No. 1186195-57-2
Description: High affinity, selective A3 antagonist
Chemical Name: 2-Phenoxy-6-(cyclohexylamino)purine hemioxalate
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

High affinity adenosine A3 receptor antagonist (Ki = 47 nM) that displays > 200-fold selectivity versus A1, A2A and A2B receptors.

Compound Libraries

MRS 3777 hemioxalate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 354.39
Formula C17H19N5O.½C2H2O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1186195-57-2
PubChem ID 56972200

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.72 50

Preparing Stock Solutions

The following data is based on the product molecular weight 354.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.64 mL 28.22 mL 56.44 mL
2.5 mM 1.13 mL 5.64 mL 11.29 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
25 mM 0.11 mL 0.56 mL 1.13 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.


References are publications that support the biological activity of the product.

Perreira et al (2005) "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J.Med.Chem. 48 4910 PMID: 16033270

Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247 PMID: 16518376

Moro et al (2006) Progress in the pursuit of therapeutic adenosine receptor antagonists. Med.Res.Rev. 26 131 PMID: 16380972

If you know of a relevant reference for MRS 3777 hemioxalate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Adenosine A3 Receptor Antagonists

Keywords: MRS 3777 hemioxalate, MRS 3777 hemioxalate supplier, High, affinity, selective, A3, antagonists, Receptors, adenosines, MRS3777, hemioxalate, Adenosine, 2403, Tocris Bioscience

1 Citation for MRS 3777 hemioxalate

Citations are publications that use Tocris products. Selected citations for MRS 3777 hemioxalate include:

Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Nature 14 201 PMID: 26597723

Do you know of a great paper that uses MRS 3777 hemioxalate from Tocris? Please let us know.

Reviews for MRS 3777 hemioxalate

There are currently no reviews for this product. Be the first to review MRS 3777 hemioxalate and earn rewards!

Have you used MRS 3777 hemioxalate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.