MRS 2219

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Cat.No. 1203 - MRS 2219 | C8H10NO5P | CAS No. 14141-47-0
Description: Potentiates P2X1-mediated responses
Chemical Name: 1,5-Dihydro-3-hydroxy-8-methyl[1,3,2]dioxaphosphepino[5,6-c]pyridin-9-ol-3-oxide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

A selective potentiator of ATP-evoked responses at rat P2X1 receptors (EC50 = 5.9 μM).

Technical Data

M. Wt 231.14
Formula C8H10NO5P
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 14141-47-0
PubChem ID 3960826
InChI Key KCAJHODRYGNBSX-UHFFFAOYSA-N
Smiles OC1=C(C)N=CC(CO2)=C1COP2(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 23.11 100

Preparing Stock Solutions

The following data is based on the product molecular weight 231.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.33 mL 21.63 mL 43.26 mL
5 mM 0.87 mL 4.33 mL 8.65 mL
10 mM 0.43 mL 2.16 mL 4.33 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Jacobson et al (1998) A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonise activation of P2X1 receptors. J.Med.Chem. 41 2201 PMID: 9632352


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Keywords: MRS 2219, MRS 2219 supplier, Potentiates, P2X1-mediated, responses, P2X, Receptors, Purinergic, modulators, purinoceptors, MRS2219, 1203, Tocris Bioscience

Citations for MRS 2219

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Literature in this Area

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