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A selective potentiator of ATP-evoked responses at rat P2X1 receptors (EC50 = 5.9 μM).
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Jacobson et al (1998) A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonise activation of P2X1 receptors. J.Med.Chem. 41 2201 PMID: 9632352
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Keywords: MRS 2219, MRS 2219 supplier, Potentiates, P2X1-mediated, responses, P2X, Receptors, Purinergic, modulators, purinoceptors, MRS2219, 1203, Tocris Bioscience
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.