MRS 1845

Discontinued Product

MRS 1845 (Cat. No. 1866) has been withdrawn from sale for commercial reasons.
Description: Potent SOCE inhibitor; blocks capacitative Ca2+ entry
Alternative Names: N-Propylargylnitrendipine
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propynyl)-3,5-pyridinedicarboxylic acid ethyl, methyl ester
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for MRS 1845

Potent blocker of store-operated Ca2+ channels; inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM).

Technical Data for MRS 1845

M. Wt 398.41
Formula C21H22N2O6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 544478-19-5
PubChem ID 11538542
Smiles O=C(OCC)C1=C(C)N(CC#C)C(C)=C(C(OC)=O)C1C2=CC([N+]([O-])=O)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for MRS 1845

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet is currently unavailable on-line.
Please contact Customer Service.

References for MRS 1845

References are publications that support the biological activity of the product.

Harper et al (2003) Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells. Biochem.Pharmacol. 65 329 PMID: 12527326

Szikra et al (2009) Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS ONE 4 e6723 PMID: 19696927

Szikra et al (2008) Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors. J.Physiol. 586 4859 PMID: 18755743

View Related Products by Product Action

View all Other Calcium Channel Blockers

Keywords: MRS 1845, MRS 1845 supplier, Potent, SOC, inhibitors, inhibits, blocks, capacitative, Ca2+, entry, Calcium, Signaling, Signalling, Agents, General, Channels, Store-Operated, MRS1845, N-Propylargylnitrendipine, Other, STIM-Orai, 1866, Tocris Bioscience

1 Citation for MRS 1845

Citations are publications that use Tocris products. Selected citations for MRS 1845 include:

Berlinguer-Palmini et al (2013) GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses. PLoS One 8 e82180 PMID: 24312407

Reviews for MRS 1845

There are currently no reviews for this product. Be the first to review MRS 1845 and earn rewards!

Have you used MRS 1845?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review