MRS 1845

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Cat.No. 1866 - MRS 1845 | C21H22N2O6 | CAS No. 544478-19-5
Description: Potent SOCE inhibitor; blocks capacitative Ca2+ entry
Alternative Names: N-Propylargylnitrendipine
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-1-(2-propynyl)-3,5-pyridinedicarboxylic acid ethyl, methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (1)

Biological Activity

Potent blocker of store-operated Ca2+ channels; inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM).

Technical Data

M. Wt 398.41
Formula C21H22N2O6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 544478-19-5
PubChem ID 11538542
InChI Key BITHABUTZRAUGT-UHFFFAOYSA-N
Smiles O=C(OCC)C1=C(C)N(CC#C)C(C)=C(C(OC)=O)C1C2=CC([N+]([O-])=O)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.98 10
ethanol 3.98 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 398.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.1 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Harper et al (2003) Dihydropyridines as inhibitors of capacitative calcium entry in leukemic HL-60 cells. Biochem.Pharmacol. 65 329 PMID: 12527326

Szikra et al (2009) Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS ONE 4 e6723 PMID: 19696927

Szikra et al (2008) Depletion of calcium stores regulates calcium influx and signal transmission in rod photoreceptors. J.Physiol. 586 4859 PMID: 18755743


If you know of a relevant reference for MRS 1845, please let us know.

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1 Citation for MRS 1845

Citations are publications that use Tocris products. Selected citations for MRS 1845 include:

Berlinguer-Palmini et al (2013) GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses. PLoS One 8 e82180 PMID: 24312407


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