MRS 1706

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Cat.No. 1584 - MRS 1706 | C27H29N5O5 | CAS No. 264622-53-9
Description: Potent and selective A2B inverse agonist
Chemical Name: N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide
Purity: ≥96% (HPLC)
Datasheet
Citations (11)
Literature

Biological Activity

Potent and selective adenosine A2B receptor inverse agonist (Ki values are 1.39, 157, 112 and 230 nM for human A2B, A1, A2A and A3 receptors respectively).

Licensing Information

Manufactured and sold under license from Adenosine Therapeutics, LLC

Technical Data

M. Wt 503.56
Formula C27H29N5O5
Storage Store at +4°C
Purity ≥96% (HPLC)
CAS Number 264622-53-9
PubChem ID 5139184
InChI Key ZKUCFFYOQOJLGT-UHFFFAOYSA-N
Smiles O=C(C(NC(C3=CC=C(OCC(NC4=CC=C(C(C)=O)C=C4)=O)C=C3)=N2)=C2N1CCC)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.52 5

Preparing Stock Solutions

The following data is based on the product molecular weight 503.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.93 mL 19.86 mL
5 mM 0.4 mL 1.99 mL 3.97 mL
10 mM 0.2 mL 0.99 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kim et al (2000) Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors. J.Med.Chem. 43 1165 PMID: 10737749

Li et al (2007) ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. J.Pharmacol.Exp.Ther. 320 637 PMID: 17077318

Kiec-Kononowicz et al (2001) New developments in A1 and A2 adenosine receptor antagonists. Pure Appl.Chem. 73 1411 PMID:


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Keywords: MRS 1706, supplier, Potent, selective, A2B, inverse, agonists, Receptors, adenosines, MRS1706, Adenosine, A2B, Receptors, Adenosine, A2B, Receptors, Tocris Bioscience

11 Citations for MRS 1706

Citations are publications that use Tocris products. Selected citations for MRS 1706 include:

Eusemann et al (2015) Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells. PLoS One 10 e0134934 PMID: 26263491

Li et al (2014) Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina. Vis Neurosci 31 237 PMID: 24844306

Rizvi et al (2013) Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis. Vascul Pharmacol 59 144 PMID: 24050945

Lee et al (2012) Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study. Front Neurosci 63 340 PMID: 23115687

Schneider et al (2010) Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease. FASEB J 24 70 PMID: 19720619

Mandapathil et al (2010) Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells. J Biol Chem 285 7176 PMID: 19858205

Long et al (2010) Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine. J Neurosci 335 781 PMID: 20855445

Epperson et al (2009) Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts. Am J Physiol Cell Physiol 296 C1171 PMID: 19244482

Xi et al (2009) Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol 47 684 PMID: 19695259

Clark et al (2009) Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation. J Neurosci 29 11237 PMID: 19741130

Newman (2005) Calcium increases in retinal glial cells evoked by light-induced neuronal activity. Korean J Anesthesiol 25 5502 PMID: 15944378


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