You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for MRS 1477
TRPV1 positive allosteric modulator. Potentiates vanilloid and proton activation of TRPV1 channels. Exhibits analgesic effects in combination with capsaicin (Cat. No. 0462) in rats. Also prolongs capsaicin-induced hypothermia in mice.
Technical Data for MRS 1477
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for MRS 1477
References are publications that support the biological activity of the product.
Kaszas et al (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J.Pharmacol.Exp.Ther. 340 152 PMID: 22005042
Lebovitz et al (2012) Positive allosteric modulation of TRPV1 as a novel analgesic mechanism. Mol.Pain 8 PMID: 22998799
Roh et al (2008) Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1). Bioorg.Med.Chem. 16 9349 PMID: 18809334
View Related Products by Product Action
Keywords: MRS 1477, MRS 1477 supplier, MRS1477, TRPV1, transient, receptors, potential, channels, positive, allosteric, modulators, analgesic, PAM, TRPV, 5246, Tocris Bioscience
Citations for MRS 1477
Citations are publications that use Tocris products.
Currently there are no citations for MRS 1477.
Reviews for MRS 1477
There are currently no reviews for this product. Be the first to review MRS 1477 and earn rewards!
Have you used MRS 1477?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image