MRS 1477

Discontinued Product

MRS 1477 (Cat. No. 5246) has been withdrawn from sale for commercial reasons.
Cat.No. 5246 - MRS 1477 | C21H27NO4S | CAS No. 212200-21-0
Description: TRPV1 positive allosteric modulator
Chemical Name: 4-Ethyl-1,4-dihydro-5-[[(2-methoxyethyl)thio]carbonyl]-6-methyl-2-phenyl-3-pyridinecarboxylic acid ethyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

TRPV1 positive allosteric modulator. Potentiates vanilloid and proton activation of TRPV1 channels. Exhibits analgesic effects in combination with capsaicin (Cat. No. 0462) in rats. Also prolongs capsaicin-induced hypothermia in mice.

Technical Data

M. Wt 389.51
Formula C21H27NO4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 212200-21-0
PubChem ID 9843337
InChI Key DMVMFYWYJCPZGS-UHFFFAOYSA-N
Smiles CCC1C(C(OCC)=O)=C(C2=CC=CC=C2)NC(C)=C1C(SCCOC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Kaszas et al (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J.Pharmacol.Exp.Ther. 340 152 PMID: 22005042

Lebovitz et al (2012) Positive allosteric modulation of TRPV1 as a novel analgesic mechanism. Mol.Pain 8 PMID: 22998799

Roh et al (2008) Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1). Bioorg.Med.Chem. 16 9349 PMID: 18809334

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Keywords: MRS 1477, MRS 1477 supplier, MRS1477, TRPV1, transient, receptors, potential, channels, positive, allosteric, modulators, analgesic, PAM, TRPV, 5246, Tocris Bioscience

Citations for MRS 1477

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Literature in this Area

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