MRS 1334

Pricing Availability   Qty
Description: Potent, highly selective hA3 antagonist
Chemical Name: 1,4-Dihydro-2-methyl-6-phenyl-4-(phenylethynyl)-3,5-pyridinedicarboxylic acid 3-ethyl-5-[(3-nitrophenyl)methyl] ester
Purity: ≥98% (HPLC)
Citations (6)

Biological Activity for MRS 1334

MRS 1334 is a potent and highly selective antagonist for the human adenosine A3 receptor. Ki values are 2.69 nM at hA3, and > 100 μM at rat A1 and rat A2A receptors.

Licensing Information

Sold with the permission of the NIH, US Patent 60/029,855

Technical Data for MRS 1334

M. Wt 522.56
Formula C31H26N2O6
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 192053-05-7
PubChem ID 4519822
Smiles CCOC(=O)C1=C(C)NC(C2=CC=CC=C2)=C(C1C#CC1=CC=CC=C1)C(=O)OCC1=CC=C(C=C1)N(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MRS 1334

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 52.26 100

Preparing Stock Solutions for MRS 1334

The following data is based on the product molecular weight 522.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.57 mL 19.14 mL
5 mM 0.38 mL 1.91 mL 3.83 mL
10 mM 0.19 mL 0.96 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets for MRS 1334

Certificate of Analysis / Product Datasheet
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References for MRS 1334

References are publications that support the biological activity of the product.

Baraldi and Borea (2000) New potent and selective human adenosine A3 receptor antagonists. TiPS 21 456 PMID: 11121831

Li et al (1998) Structure-activity relationships and molecular modeling of 3,5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J.Med.Chem. 41 3186 PMID: 9703464

Corriden et al (2013) Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO.Rep. 14 726 PMID: 23817552

If you know of a relevant reference for MRS 1334, please let us know.

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Keywords: MRS 1334, MRS 1334 supplier, Potent, selective, hA3, antagonists, Receptors, adenosines, MRS1334, Adenosine, A3, 1385, Tocris Bioscience

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