MRS 1334

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Cat.No. 1385 - MRS 1334 | C31H26N2O6 | CAS No. 192053-05-7
Description: Potent, highly selective hA3 antagonist
Chemical Name: 1,4-Dihydro-2-methyl-6-phenyl-4-(phenylethynyl)-3,5-pyridinedicarboxylic acid 3-ethyl-5-[(3-nitrophenyl)methyl] ester
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews
Literature

Biological Activity

Potent and highly selective antagonist for the human adenosine A3 receptor. Ki values are 2.69 nM at hA3, and > 100 μM at rat A1 and rat A2A receptors.

Licensing Information

Sold with the permission of the NIH, US Patent 60/029,855

Technical Data

M. Wt 522.56
Formula C31H26N2O6
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 192053-05-7
PubChem ID 4519822
InChI Key QFLOJAMZLQXHFS-UHFFFAOYSA-N
Smiles CCOC(=O)C1=C(C)NC(C2=CC=CC=C2)=C(C1C#CC1=CC=CC=C1)C(=O)OCC1=CC=C(C=C1)N(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.26 100

Preparing Stock Solutions

The following data is based on the product molecular weight 522.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.57 mL 19.14 mL
5 mM 0.38 mL 1.91 mL 3.83 mL
10 mM 0.19 mL 0.96 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Baraldi and Borea (2000) New potent and selective human adenosine A3 receptor antagonists. TiPS 21 456 PMID: 11121831

Li et al (1998) Structure-activity relationships and molecular modeling of 3,5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J.Med.Chem. 41 3186 PMID: 9703464


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Keywords: MRS 1334, supplier, Potent, selective, hA3, antagonists, Receptors, adenosines, MRS1334, Adenosine, A3, Receptors, Adenosine, A3, Receptors, Tocris Bioscience

6 Citations for MRS 1334

Citations are publications that use Tocris products. Selected citations for MRS 1334 include:

Alsharif et al (2015) Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis. Vascul Pharmacol 71 201 PMID: 25869515

Corriden et al (2013) Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. Nat Commun 14 726 PMID: 23817552

Lee et al (2012) Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study. EMBO Rep 63 340 PMID: 23115687

Varani et al (2011) A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release. Arthritis Res Ther 13 R197 PMID: 22146575

Guerreiro et al (2008) Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels. Mol Pharmacol 74 980 PMID: 18621927

Eltzschig et al (2004) Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood 104 3986 PMID: 15319286


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