MRE 3008F20

Pricing Availability Delivery Time Qty
Cat.No. 4041 - MRE 3008F20 | C21H20N8O3 | CAS No. 252979-43-4
Description: Highly potent and selective adenosine A3 receptor antagonist
Chemical Name: N-[2-(2-Furanyl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-N'-(4-methoxyphenyl)urea
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent adenosine A3 receptor competitive antagonist. Selective for human A3 receptors over human A1 and A2A receptors (Ki values are 0.29, 141 and 1197 nM respectively). Potently inhibits agonist-induced cyclic AMP elevation in resting T lymphocytes (IC50 = 5 nM).

Technical Data

M. Wt 432.44
Formula C21H20N8O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 252979-43-4
PubChem ID 5310960
InChI Key CJRNHKSLHHWUAB-UHFFFAOYSA-N
Smiles O=C(NC4=CC=C(OC)C=C4)NC2=NC1=NN(CCC)C=C1C3=NC(C5=CC=CO5)=NN23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 432.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.56 mL 23.12 mL
5 mM 0.46 mL 2.31 mL 4.62 mL
10 mM 0.23 mL 1.16 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Gessi et al (2004) Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol.Pharmacol. 65 711 PMID: 14978250

Varani et al (2010) Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes. Br.J.Pharmacol. 160 101 PMID: 20331607

Baraldi et al (1999) Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. J.Med.Chem. 42 4473 PMID: 10579811


If you know of a relevant reference for MRE 3008F20, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Adenosine A3 Receptor Antagonists

Keywords: MRE 3008F20, supplier, adenosine, A3, receptors, potent, selective, competitive, antagonists, A3AR, MRE3008F20, hA3, Adenosine, A3, Receptors, Tocris Bioscience

Citations for MRE 3008F20

Citations are publications that use Tocris products.

Currently there are no citations for MRE 3008F20. Do you know of a great paper that uses MRE 3008F20 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pathways for MRE 3008F20

Protocols

TODO: Add Protocols