MRE 3008F20

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Cat.No. 4041 - MRE 3008F20 | C21H20N8O3 | CAS No. 252979-43-4
Description: Highly potent and selective adenosine A3 receptor antagonist
Chemical Name: N-[2-(2-Furanyl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-N'-(4-methoxyphenyl)urea
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Potent adenosine A3 receptor competitive antagonist. Selective for human A3 receptors over human A1 and A2A receptors (Ki values are 0.29, 141 and 1197 nM respectively). Potently inhibits agonist-induced cyclic AMP elevation in resting T lymphocytes (IC50 = 5 nM).

Technical Data

M. Wt 432.44
Formula C21H20N8O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 252979-43-4
PubChem ID 5310960
InChI Key CJRNHKSLHHWUAB-UHFFFAOYSA-N
Smiles O=C(NC4=CC=C(OC)C=C4)NC2=NC1=NN(CCC)C=C1C3=NC(C5=CC=CO5)=NN23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 432.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.62 mL 23.12 mL 46.25 mL
2.5 mM 0.92 mL 4.62 mL 9.25 mL
5 mM 0.46 mL 2.31 mL 4.62 mL
25 mM 0.09 mL 0.46 mL 0.92 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Gessi et al (2004) Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol.Pharmacol. 65 711 PMID: 14978250

Varani et al (2010) Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes. Br.J.Pharmacol. 160 101 PMID: 20331607

Baraldi et al (1999) Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. J.Med.Chem. 42 4473 PMID: 10579811


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Citations for MRE 3008F20

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Literature in this Area

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