Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMRE 3008F20
Discontinued Product
4041 has been discontinued.
View all Adenosine A<sub>3</sub> Receptors products.
Description: Highly potent and selective adenosine A3 receptor antagonist
Chemical Name: N-[2-(2-Furanyl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-N'-(4-methoxyphenyl)urea
Purity: ≥98% (HPLC)
Biological Activity for MRE 3008F20
MRE 3008F20 is a potent adenosine A3 receptor competitive antagonist. Selective for human A3 receptors over human A1 and A2A receptors (Ki values are 0.29, 141 and 1197 nM respectively). Potently inhibits agonist-induced cyclic AMP elevation in resting T lymphocytes (IC50 = 5 nM).
Technical Data for MRE 3008F20
| M. Wt | 432.44 |
| Formula | C21H20N8O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 252979-43-4 |
| PubChem ID | 5310960 |
| InChI Key | CJRNHKSLHHWUAB-UHFFFAOYSA-N |
| Smiles | O=C(NC4=CC=C(OC)C=C4)NC2=NC1=NN(CCC)C=C1C3=NC(C5=CC=CO5)=NN23 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MRE 3008F20
References for MRE 3008F20
References are publications that support the biological activity of the product.
Gessi et al (2004) Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol.Pharmacol. 65 711 PMID: 14978250
Varani et al (2010) Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes. Br.J.Pharmacol. 160 101 PMID: 20331607
Baraldi et al (1999) Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. J.Med.Chem. 42 4473 PMID: 10579811
View Related Products by Target
View Related Products by Product Action
Keywords: MRE 3008F20, MRE 3008F20 supplier, adenosine, A3, receptors, potent, selective, competitive, antagonists, A3AR, MRE3008F20, hA3, Adenosine, Receptors, 4041, Tocris Bioscience
Citations for MRE 3008F20
Citations are publications that use Tocris products.
Currently there are no citations for MRE 3008F20.
Reviews for MRE 3008F20
There are currently no reviews for this product. Be the first to review MRE 3008F20 and earn rewards!
Have you used MRE 3008F20?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image