Motilin (human, porcine)

Pricing Availability   Qty
Cat.No. 2264 - Motilin (human, porcine) | Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln | CAS No. 52906-92-0
Description: Endogenous peptide regulator of gastrointestinal motility
Datasheet
Citations (1)
Reviews (1)
Literature

Biological Activity

Endogenous motilin receptor ligand (Ki = 2.3 nM) that regulates gastrointestinal motor function. Stimulates contraction of gut smooth muscle (EC50 = 1 nM) and increases pepsin release.

Technical Data

M. Wt 2699.07
Formula C120H188N34O35S
Sequence FVPIFTYGELQRMQEKERNKGQ
Storage Desiccate at -20°C
CAS Number 52906-92-0
PubChem ID 16136567
InChI Key LVRVABPNVHYXRT-BQWXUCBYSA-N
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Itoh (1997) Motilin and clinical application. Peptides 18 593 PMID: 9210180

Coulie et al (2001) Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. J.Biol.Chem. 276 35518 PMID: 11461914

Huang et al (2005) Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. Am.J.Physiol.Gastrointest.Liver Physiol. 288 G23 PMID: 15591586


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Keywords: Motilin (human, porcine), Motilin (human, porcine) supplier, Endogenous, peptide, regulator, gastrointestinal, motility, Motilin, Receptors, 2264, Tocris Bioscience

1 Citation for Motilin (human, porcine)

Citations are publications that use Tocris products. Selected citations for Motilin (human, porcine) include:

Broad and Sanger (2013) The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin. Br J Pharmacol 168 1859 PMID: 23190027


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Reviews for Motilin (human, porcine)

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GI tissue bath
By John Broad on 01/05/2018
Assay Type: In Vitro
Species: Human

Caused contraction of GI smooth muscle 10-300 nM

Soluble in H2O

PMID: 22537158
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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