Home / Pharmacology / 7-TM Receptors / Peptide Receptors / Motilin Receptor

Motilin Receptor

The motilin receptor is a Gq/11-protein-coupled receptor that mediates progastrokinetic effects. It is found at its highest concentrations in the nerves of the antral wall of the stomach and is also found at significant levels throughout the smooth muscle of the upper GI tract.

Products
Background
Literature
Gene Data

Agonists
Cat. No. Product Name / Activity
2264 Motilin (human, porcine)
Endogenous peptide regulator of gastrointestinal motility

Antagonists
Cat. No. Product Name / Activity
5074 ANQ 11125
Selective motilin receptor antagonist
4934 MA 2029
Potent and selective, competitive motilin receptor antagonist; orally active

The motilin receptor is a Gq/11-protein-coupled receptor that mediates progastrokinetic effects. It is found at its highest concentrations in the nerves of the antral wall of the stomach and is also found at significant levels throughout the smooth muscle of the upper GI tract and in the enteric nervous system.

The motilin receptor promotes gastric emptying after food intake and increases smooth muscle contraction in the GI tract. The motilin receptor has not been identified in rodents, but has been cloned in rabbits and humans. The human motilin receptor gene is localized on chromosome 13q14-q21.

External sources of pharmacological information for Motilin Receptor :

Literature for Motilin Receptor

Tocris offers the following scientific literature for Motilin Receptor to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing

Motilin Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human MLNR NM_001507 O43193