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Description: Selective orthostatic agonist of hFFA2-DREADDs
Chemical Name: 4-Methoxy-3-methylbenzoic acid
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for MOMBA

MOMBA is a selective orthosteric agonist for human free fatty acid 2 (hFFA2) engineered receptors, designer receptors activated by designer drugs (DREADD), it shows no activity to wild-type hFFA2, hFFA3, and mouse FFA2. MOMBA inhibit forskolin-stimulated cAMP levels in cells expressing the hFFA2-DREADD receptor with improved potency and equivalent efficacy to Sorbic acid (Cat. No. 7119). In hFFA2-DREADD transgenic mice, MOMBA treatment significantly reduces gut transit and promotes concentration-dependent release of GLP-1 from colonic crypts. Orally bioavailable.

Technical Data for MOMBA

M. Wt 166.17
Formula C9H10O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 6880-04-2
PubChem ID 2759583
Smiles O=C(O)C1=CC=C(OC)C(=C1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MOMBA

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 16.62 100
ethanol 16.62 100

Preparing Stock Solutions for MOMBA

The following data is based on the product molecular weight 166.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.02 mL 30.09 mL 60.18 mL
5 mM 1.2 mL 6.02 mL 12.04 mL
10 mM 0.6 mL 3.01 mL 6.02 mL
50 mM 0.12 mL 0.6 mL 1.2 mL

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Product Datasheets for MOMBA

Certificate of Analysis / Product Datasheet
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References for MOMBA

References are publications that support the biological activity of the product.

Barki et al (2022) Chemogenetics defines a short-chain fatty acid receptor gut-brain axis. Elife 11 e73777 PMID: 35229717

Miura et al (2022) Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches. RSC Chem.Biol. 3 269 PMID: 35359495

Milligan et al (2021) Chemogenetic approaches to explore the functions of free fatty acid receptor 2. Trends Pharmacol.Sci. 42 191 PMID: 33495026

If you know of a relevant reference for MOMBA, please let us know.

Keywords: MOMBA, MOMBA supplier, orthostatic, agonist, free, fatty, acid, receptor, 2, FFA2, hFFA2, designer, receptors, activated, by, drugs, DREADD, DREADDs, Free, Fatty, Acid, Receptors, 7926, Tocris Bioscience

Citations for MOMBA

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Currently there are no citations for MOMBA. Do you know of a great paper that uses MOMBA from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Chemogenetics Research Bulletin

Chemogenetics Research Bulletin

Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.

Allosteric GPCR Pharmacology Poster

Allosteric GPCR Pharmacology Poster

G protein-coupled receptors (GPCRs) are intrinsically allosteric proteins. This poster provides insights into allosteric mechanisms of GPCR biology, highlighting key facets of GPCR allostery and therapeutic applications of allosteric modulators.

GPCR Efficacy and Biased Agonism Poster

GPCR Efficacy and Biased Agonism Poster

GPCRs can interact with multiple distinct transducers or regulatory proteins and these can be preferentially engaged in an agonist-specific manner giving rise to biased agonism. This poster discusses cutting edge GPCR signaling pharmacology and highlights therapeutic applications of biased agonism.