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Description: Activator of hFFA2-DREADDs
Chemical Name: (2E,4E)-2,4-Hexenoic acid
Purity: ≥98% (HPLC)
Biological Activity for Sorbic acid
Sorbic acid is an activator of hFFA2-DREADDs. Inhibits forskolin-induced cAMP production (IC50 ∼ 1 μM) and promotes accumulation of inositol monophosphates (IC50 >1 μM) in cells expressing hFFA2-DREADD. Promotes the release of GLP-1 from colonic crypts derived from hFFA2-DREADD-expressing mice.
Technical Data for Sorbic acid
| M. Wt | 112.13 |
| Formula | C6H8O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 110-44-1 |
| PubChem ID | 643460 |
| InChI Key | WSWCOQWTEOXDQX-MQQKCMAXSA-N |
| Smiles | CC=CC=CC(=O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Sorbic acid
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.21 | 100 | |
| ethanol | 11.21 | 100 |
Preparing Stock Solutions for Sorbic acid
The following data is based on the product molecular weight 112.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 8.92 mL | 44.59 mL | 89.18 mL |
| 5 mM | 1.78 mL | 8.92 mL | 17.84 mL |
| 10 mM | 0.89 mL | 4.46 mL | 8.92 mL |
| 50 mM | 0.18 mL | 0.89 mL | 1.78 mL |
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Product Datasheets for Sorbic acid
References for Sorbic acid
References are publications that support the biological activity of the product.
Bolognini et al (2019) Chemogenetics defines receptor-mediated functions of short chain free fatty acids. Nat.Chem.Biol. 15 489 PMID: 30992568
If you know of a relevant reference for Sorbic acid, please let us know.
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Citations for Sorbic acid
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Chemogenetics Research Bulletin
Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.
Allosteric GPCR Pharmacology Poster
G protein-coupled receptors (GPCRs) are intrinsically allosteric proteins. This poster provides insights into allosteric mechanisms of GPCR biology, highlighting key facets of GPCR allostery and therapeutic applications of allosteric modulators.
GPCR Efficacy and Biased Agonism Poster
GPCRs can interact with multiple distinct transducers or regulatory proteins and these can be preferentially engaged in an agonist-specific manner giving rise to biased agonism. This poster discusses cutting edge GPCR signaling pharmacology and highlights therapeutic applications of biased agonism.