Sorbic acid

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Cat.No. 7119 - Sorbic acid | C6H8O2 | CAS No. 110-44-1
Description: Activator of hFFA2-DREADDs
Chemical Name: (2E,4E)-2,4-Hexenoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Activator of hFFA2-DREADDs. Inhibits forskolin-induced cAMP production (IC50 ∼ 1 μM) and promotes accumulation of inositol monophosphates (IC50 >1 μM) in cells expressing hFFA2-DREADD. Promotes the release of GLP-1 from colonic crypts derived from hFFA2-DREADD-expressing mice.

Technical Data

M. Wt 112.13
Formula C6H8O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 110-44-1
PubChem ID 643460
InChI Key WSWCOQWTEOXDQX-MQQKCMAXSA-N
Smiles CC=CC=CC(=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.21 100
ethanol 11.21 100

Preparing Stock Solutions

The following data is based on the product molecular weight 112.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 8.92 mL 44.59 mL 89.18 mL
5 mM 1.78 mL 8.92 mL 17.84 mL
10 mM 0.89 mL 4.46 mL 8.92 mL
50 mM 0.18 mL 0.89 mL 1.78 mL

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References

References are publications that support the biological activity of the product.

Bolognini et al (2019) Chemogenetics defines receptor-mediated functions of short chain free fatty acids. Nat.Chem.Biol. 15 489 PMID: 30992568


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Citations for Sorbic acid

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Literature in this Area

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