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Description: Psychostimulant
Alternative Names: CRL 40476
Chemical Name: 2-[(Diphenylmethyl)sulfinyl]acetamide
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Modafinil

Modafinil is a psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Modafinil promotes vigilance and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.

Technical Data for Modafinil

M. Wt 273.35
Formula C15H15NO2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 68693-11-8
PubChem ID 4236
Smiles O=S(CC(N)=O)C(C2=CC=CC=C2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Modafinil

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.5 75
ethanol 2.73 10

Preparing Stock Solutions for Modafinil

The following data is based on the product molecular weight 273.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 4.88 mL 24.39 mL 48.78 mL
3.75 mM 0.98 mL 4.88 mL 9.76 mL
7.5 mM 0.49 mL 2.44 mL 4.88 mL
37.5 mM 0.1 mL 0.49 mL 0.98 mL

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Product Datasheets for Modafinil

Certificate of Analysis / Product Datasheet
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References for Modafinil

References are publications that support the biological activity of the product.

Ferraro et al (1997) Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and DA uptake blockers. Biol.Psychiatry 42 1181 PMID: 9426889

Jenner et al (2000) Antiparkinsonian and neuroprotective effects of moda. in the mtpt-treated common marmoset. Exp.Brain Res. 133 178 PMID: 10968218

Madras et al (2006) Modafinil occupies DA and NE transporters in vivo and modulates the transporters and trace amine activity in vitro. J.Pharmacol.Exp.Ther. 319 561 PMID: 16885432

If you know of a relevant reference for Modafinil, please let us know.

Keywords: Modafinil, Modafinil supplier, Psychostimulant, Adrenergic, Compounds, Adrenoceptors, Receptors, Dopaminergic, Dopamine, GABA, CRL40476, CRL, 40476, Related, Dopaminergic-Related, Miscellaneous, GABAB, 1811, Tocris Bioscience

1 Citation for Modafinil

Citations are publications that use Tocris products. Selected citations for Modafinil include:

Yu et al (2019) Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness. Sleep 42 PMID: 30722053

Do you know of a great paper that uses Modafinil from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.