You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Promotes vigilence and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 273.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.75 mM||4.88 mL||24.39 mL||48.78 mL|
|3.75 mM||0.98 mL||4.88 mL||9.76 mL|
|7.5 mM||0.49 mL||2.44 mL||4.88 mL|
|37.5 mM||0.1 mL||0.49 mL||0.98 mL|
References are publications that support the biological activity of the product.
Ferraro et al (1997) Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and DA uptake blockers. Biol.Psychiatry 42 1181 PMID: 9426889
Jenner et al (2000) Antiparkinsonian and neuroprotective effects of moda. in the mtpt-treated common marmoset. Exp.Brain Res. 133 178 PMID: 10968218
Madras et al (2006) Modafinil occupies DA and NE transporters in vivo and modulates the transporters and trace amine activity in vitro. J.Pharmacol.Exp.Ther. 319 561 PMID: 16885432
If you know of a relevant reference for Modafinil, please let us know.
View Related Products by Target
Keywords: Modafinil, Modafinil supplier, Psychostimulant, Adrenergic, Compounds, Adrenoceptors, Receptors, Dopaminergic, Dopamine, GABA, CRL40476, CRL, 40476, Related, Dopaminergic-Related, Miscellaneous, GABAB, 1811, Tocris Bioscience
1 Citation for Modafinil
Citations are publications that use Tocris products. Selected citations for Modafinil include:
Yu et al (2019) Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness. Sleep 42 PMID: 30722053
Do you know of a great paper that uses Modafinil from Tocris? Please let us know.
Reviews for Modafinil
There are currently no reviews for this product. Be the first to review Modafinil and earn rewards!
Have you used Modafinil?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.