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Biological Activity for Modafinil
Modafinil is a psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Modafinil promotes vigilance and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.
Technical Data for Modafinil
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Modafinil
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Modafinil
The following data is based on the product molecular weight 273.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.75 mM||4.88 mL||24.39 mL||48.78 mL|
|3.75 mM||0.98 mL||4.88 mL||9.76 mL|
|7.5 mM||0.49 mL||2.44 mL||4.88 mL|
|37.5 mM||0.1 mL||0.49 mL||0.98 mL|
References for Modafinil
References are publications that support the biological activity of the product.
Ferraro et al (1997) Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and DA uptake blockers. Biol.Psychiatry 42 1181 PMID: 9426889
Jenner et al (2000) Antiparkinsonian and neuroprotective effects of moda. in the mtpt-treated common marmoset. Exp.Brain Res. 133 178 PMID: 10968218
Madras et al (2006) Modafinil occupies DA and NE transporters in vivo and modulates the transporters and trace amine activity in vitro. J.Pharmacol.Exp.Ther. 319 561 PMID: 16885432
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Keywords: Modafinil, Modafinil supplier, Psychostimulant, Adrenergic, Compounds, Adrenoceptors, Receptors, Dopaminergic, Dopamine, GABA, CRL40476, CRL, 40476, Related, Dopaminergic-Related, Miscellaneous, GABAB, 1811, Tocris Bioscience
1 Citation for Modafinil
Citations are publications that use Tocris products. Selected citations for Modafinil include:
Yu et al (2019) Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness. Sleep 42 PMID: 30722053
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.