Modafinil

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Cat.No. 1811 - Modafinil | C15H15NO2S | CAS No. 68693-11-8
Description: Psychostimulant
Alternative Names: CRL 40476
Chemical Name: 2-[(Diphenylmethyl)sulfinyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Promotes vigilence and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.

Technical Data

M. Wt 273.35
Formula C15H15NO2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 68693-11-8
PubChem ID 4236
InChI Key YFGHCGITMMYXAQ-UHFFFAOYSA-N
Smiles O=S(CC(N)=O)C(C2=CC=CC=C2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.5 75
ethanol 2.73 10

Preparing Stock Solutions

The following data is based on the product molecular weight 273.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.66 mL 18.29 mL 36.58 mL
5 mM 0.73 mL 3.66 mL 7.32 mL
10 mM 0.37 mL 1.83 mL 3.66 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ferraro et al (1997) Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers. Biol.Psychiatry 42 1181 PMID: 9426889

Jenner et al (2000) Antiparkinsonian and neuroprotective effects of modafinil in the mtpt-treated common marmoset. Exp.Brain Res. 133 178 PMID: 10968218

Madras et al (2006) Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J.Pharmacol.Exp.Ther. 319 561 PMID: 16885432


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Keywords: Modafinil, supplier, Psychostimulant, Adrenergic, Compounds, Adrenoceptors, Receptors, Dopaminergic, Dopamine, GABA, CRL40476, CRL, 40476, Adrenergic, Related, Compounds, Dopaminergic-Related, Miscellaneous, GABA, GABAB, Receptors, Adrenergic, Related, Compounds, Tocris Bioscience

Citations for Modafinil

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