MNITMT

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Cat.No. 2492 - MNITMT | C7H8N6O2S | CAS No. 177653-76-8
Description: Novel, non-toxic immunosuppressive agent
Alternative Names: NSC 631156
Chemical Name: 4-Methyl-3-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-4H-1,2,4-triazole
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Novel, non-toxic immunosuppressive agent. Inhibits human mixed lymphocyte reaction in vitro (ED50 = 2.7 μM) and prolongs skin graft survival in mice. Produces a 98.1% reduction in antibody response following oral administration in rabbits.

Technical Data

M. Wt 240.24
Formula C7H8N6O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 177653-76-8
PubChem ID 364622
InChI Key NMBDIMPYACLUDE-UHFFFAOYSA-N
Smiles CN1C=NN=C1SC1=C(N=CN1C)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.8 20
water 2.4 10

Preparing Stock Solutions

The following data is based on the product molecular weight 240.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.16 mL 20.81 mL 41.63 mL
5 mM 0.83 mL 4.16 mL 8.33 mL
10 mM 0.42 mL 2.08 mL 4.16 mL
50 mM 0.08 mL 0.42 mL 0.83 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Crawford et al (1996) Rational design of novel immunosuppressive drugs: analogues of azathioprine lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects. J.Med.Chem. 39 2690 PMID: 8709098

Al-Safi et al (2003) Comparison of the effects of azathioprine and its novel non-mercaptopurine analog on antibody response in rabbits. Pol.J.Pharmacol. 55 239 PMID: 12926553


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Keywords: MNITMT, supplier, Immunosuppressant, NSC631156, NSC, 631156, Immunosuppressants, Tocris Bioscience

Citations for MNITMT

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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