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Cat.No. 2492 - MNITMT | C7H8N6O2S | CAS No. 177653-76-8
Description: Novel, non-toxic immunosuppressive agent
Alternative Names: NSC 631156
Chemical Name: 4-Methyl-3-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-4H-1,2,4-triazole
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity

Novel, non-toxic immunosuppressive agent. Inhibits human mixed lymphocyte reaction in vitro (ED50 = 2.7 μM) and prolongs skin graft survival in mice. Produces a 98.1% reduction in antibody response following oral administration in rabbits.

Previously sold as Cat. No. 0564.

Technical Data

M. Wt 240.24
Formula C7H8N6O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 177653-76-8
PubChem ID 364622
Smiles CN1C=NN=C1SC1=C(N=CN1C)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 2.4 10

Preparing Stock Solutions

The following data is based on the product molecular weight 240.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 41.63 mL 208.13 mL 416.25 mL
0.5 mM 8.33 mL 41.63 mL 83.25 mL
1 mM 4.16 mL 20.81 mL 41.63 mL
5 mM 0.83 mL 4.16 mL 8.33 mL

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References are publications that support the biological activity of the product.

Crawford et al (1996) Rational design of novel immunosuppressive drugs: analogues of azathio. lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects. J.Med.Chem. 39 2690 PMID: 8709098

Al-Safi et al (2003) Comparison of the effects of azathio. and its novel non-mercaptopurine analog on antibody response in rabbits. Pol.J.Pharmacol. 55 239 PMID: 12926553

If you know of a relevant reference for MNITMT, please let us know.

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Keywords: MNITMT, MNITMT supplier, Immunosuppressant, NSC631156, NSC, 631156, Immunosuppressants, 2492, Tocris Bioscience

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Literature in this Area

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