Novel, non-toxic immunosuppressive agent. Inhibits human mixed lymphocyte reaction in vitro (ED50 = 2.7 μM) and prolongs skin graft survival in mice. Produces a 98.1% reduction in antibody response following oral administration in rabbits.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 240.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.16 mL||20.81 mL||41.63 mL|
|5 mM||0.83 mL||4.16 mL||8.33 mL|
|10 mM||0.42 mL||2.08 mL||4.16 mL|
|50 mM||0.08 mL||0.42 mL||0.83 mL|
References are publications that support the products' biological activity.
Crawford et al (1996) Rational design of novel immunosuppressive drugs: analogues of azathioprine lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects. J.Med.Chem. 39 2690 PMID: 8709098
Al-Safi et al (2003) Comparison of the effects of azathioprine and its novel non-mercaptopurine analog on antibody response in rabbits. Pol.J.Pharmacol. 55 239 PMID: 12926553
If you know of a relevant reference for MNITMT, please let us know.
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Keywords: MNITMT, supplier, Immunosuppressant, NSC631156, NSC, 631156, Immunosuppressants, Immunosuppressants, Tocris Bioscience
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