MN 64

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Cat.No. 5084 - MN 64 | C18H16O2 | CAS No. 92831-11-3
Description: Potent and selective tankyrase inhibitor
Chemical Name: 2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective tankyrase (TNKS) inhibitor (IC50 values are 6 and 72 nM for TNKS1 and TNKS2 respectively). Has no significant effect on PARP-1 or PARP-2 (IC50 >19 μM). Inhibits WNT/β-catenin signaling-dependent Super-TopFlash (STF) luciferase activity.

Technical Data

M. Wt 264.32
Formula C18H16O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 92831-11-3
PubChem ID 2802462
InChI Key PYTOHIUBXSJKQH-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC=C1OC(C3=CC=C(C(C)C)C=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.43 100
ethanol 26.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 264.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.78 mL 18.92 mL 37.83 mL
5 mM 0.76 mL 3.78 mL 7.57 mL
10 mM 0.38 mL 1.89 mL 3.78 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Narwal et al (2013) Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem. 56 7880 PMID: 24116873


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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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