MN 64

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Cat.No. 5084 - MN 64 | C18H16O2 | CAS No. 92831-11-3
Description: Potent and selective tankyrase inhibitor
Chemical Name: 2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity

Potent and selective tankyrase (TNKS) inhibitor (IC50 values are 6 and 72 nM for TNKS1 and TNKS2 respectively). Has no significant effect on PARP-1 or PARP-2 (IC50 >19 μM). Inhibits WNT/β-catenin signaling-dependent Super-TopFlash (STF) luciferase activity.

Technical Data

M. Wt 264.32
Formula C18H16O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 92831-11-3
PubChem ID 2802462
Smiles O=C2C1=CC=CC=C1OC(C3=CC=C(C(C)C)C=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.43 100
ethanol 26.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 264.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.78 mL 18.92 mL 37.83 mL
5 mM 0.76 mL 3.78 mL 7.57 mL
10 mM 0.38 mL 1.89 mL 3.78 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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References are publications that support the biological activity of the product.

Narwal et al (2013) Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J.Med.Chem. 56 7880 PMID: 24116873

If you know of a relevant reference for MN 64, please let us know.

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Citations for MN 64

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